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Medivation's Dimebon(TM) Stabilizes Behavioral Symptoms in Alzheimer's Disease Patients, Resulting in Reduced Caregiver Distress
Date:3/15/2008

-- Neuropsychiatric Data from Pivotal Trial Presented at Annual Meeting of

American Association for Geriatric Psychiatry --

SAN FRANCISCO and ORLANDO, Fla., March 15 /PRNewswire-FirstCall/ -- Medivation, Inc. (Nasdaq: MDVN) today announced that clinical results from its first pivotal trial of Dimebon(TM) showed that behavioral symptoms were stabilized in patients with mild-to-moderate Alzheimer's disease (AD) over a one-year period, resulting in decreased caregiver distress. Benefits of Dimebon were seen across most behavioral symptoms and were most prominent in the symptoms of depression, apathy, hallucinations, irritability and motor disturbance (i.e., engaging in repetitive activities, such as pacing around the house). The data were presented today during a poster session on new research topics at the annual meeting of the American Association for Geriatric Psychiatry (AAGP) by Jeffrey Cummings, M.D., the Augustus Rose Professor of Neurology at the University of California, Los Angeles, and Director of the UCLA Alzheimer's Disease Center.

"These findings are noteworthy because behavioral symptoms are among the most difficult aspects of Alzheimer's disease that caregivers face, and often result in institutionalization of patients," said Dr. Cummings. "Given these behavioral data, together with the overall efficacy findings shown in the previously-reported Dimebon pivotal trial, I believe that Dimebon is one of the most promising Alzheimer's disease compounds in development."

Dimebon Improved NPI Score at Both Six Months and One Year

The data presented at the AAGP conference included results of an analysis of the 12 subdomains of the Neuropsychiatric Inventory (NPI), a measure of the behavioral sy
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SOURCE Medivation, Inc.
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