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Medivation's Dimebon(TM) Significantly Improved Thinking and Memory in Alzheimer's Disease Patients Over One Year
Date:4/17/2008

- Cognitive Function Data from Pivotal Trial Presented at American Academy

of Neurology 60th Annual Meeting -

SAN FRANCISCO and CHICAGO, April 17 /PRNewswire-FirstCall/ -- Medivation, Inc. (Nasdaq: MDVN) today announced that Alzheimer's patients treated with the investigational drug Dimebon(TM) showed improvement in the key aspects of cognitive function over a one-year period compared with placebo. The improvement occurred in not only memory and language, but also in more complex functions such as awareness of time and place, and praxis -- the process of getting an idea and initiating and completing a new motor task. These clinical results were generated during a pivotal trial of Dimebon in patients with mild-to-moderate Alzheimer's disease (AD).

The data were presented today during an oral presentation at the 60th Annual Meeting of the American Academy of Neurology (AAN) by Steven H. Ferris, Ph.D., the Gerald J. and Dorothy R. Friedman Professor of Psychiatry at New York University and director of the NYU Alzheimer's Disease Center.

"The finding that Dimebon improved memory, orientation, language and praxis in Alzheimer's disease patients suggests that it provides a broad rather than a selective cognitive benefit," said Dr. Ferris. "This is an important finding given that deficits in memory and thinking are one of the hallmarks of Alzheimer's disease and cause patients and caregivers significant distress."

Dimebon Significantly Improved Cognitive Function at One Year

The data presented at the AAN Annual Meeting included results of an analysis of the 11 subdomains of the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog), a standardized measure of cognition in patients
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