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Medivation's Dimebon(TM) Significantly Improved Daily Function in Alzheimer's Disease Patients, Resulting in Reduced Need for Caregiver Assistance
Date:4/15/2008

hs and One Year

The data presented at the AAN Annual Meeting included results of an analysis of the subdomains of the Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) endpoint, a measure of day-to-day function in AD patients, and of caregiver time as measured by the Resource Utilization in Dementia (RUD-lite) questionnaire. During the study, the ADCS-ADL was assessed at the beginning of the study and at weeks 12, 26, 39 and 52. Caregiver time was assessed using the RUD-lite at the start of the study and at week 26.

Results showed that Dimebon-treated patients were significantly improved on the ADL score compared with placebo-treated patients after six months (p=0.01) and one year of treatment (p=0.004). Among patients treated with Dimebon, significant (p<0.05) improvements were observed in the subdomains of eating, toilet use, phone use, conversation, preparing meals, traveling, keeping appointments, reading and using household appliances after one year.

Dimebon Reduced Daily Caregiver Assistance Time

Importantly, after six months of treatment, caregivers of the Dimebon-treated patients were spending an average of 51 minutes less on ADL assistance during a typical day compared to caregivers of placebo-treated patients (p=0.0004). Patients on placebo required an increase in daily caregiver time from 5.1 to 5.4 hours, while caregivers of Dimebon-treated patients reported a decrease from 4.4 to 3.9 hours daily.

"Anyone who has experienced Alzheimer's disease in a loved one knows that it is a devastating disease that steals from patients their ability to think and care for themselves," said Lynn Seely, M.D., chief medical officer of Medivation. "We are very encouraged that Dimebon improved and sustained the functional capabilities of patients with Alzheimer's disease after one year, and that patients required less caregiver assistance. A second pivotal trial designed to confirm these results will be starting
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SOURCE Medivation, Inc.
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