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Medivation's Dimebon(TM) Significantly Improved Daily Function in Alzheimer's Disease Patients, Resulting in Reduced Need for Caregiver Assistance
Date:4/15/2008

- Activities of Daily Living Data from Pivotal Trial Presented at American

Academy of Neurology 60th Annual Meeting -

SAN FRANCISCO and CHICAGO, April 15 /PRNewswire-FirstCall/ -- Medivation, Inc. (Nasdaq: MDVN) today announced that Alzheimer's patients taking the investigational drug Dimebon(TM) showed significant improvement in their ability to perform daily tasks over a one-year period compared to placebo. This improvement allowed caregivers to save an average of nearly one hour (51 minutes) each day caring for patients. The benefits of Dimebon were seen in eating, toilet use, phone use, conversation, meal preparation, traveling, keeping appointments, reading and using household appliances. These clinical results were generated during a pivotal trial of Dimebon in patients with mild-to-moderate Alzheimer's disease (AD).

The data were presented today during a poster session on "Aging and Dementia: Treatment" at the 60th Annual Meeting of the American Academy of Neurology (AAN) by Rachelle Doody, M.D., Ph.D., the Effie Marie Cain Chair in Alzheimer's Disease Research at the Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine in Houston.

"After one year of therapy with Dimebon, Alzheimer's disease patients performed better in daily function than patients who did not get Dimebon, allowing them to maintain their functionality and decreasing the time needed by caregivers to assist with daily activities," said Dr. Doody. "In contrast, placebo-treated patients declined in function and required greater caregiver assistance, as would be expected given the natural progression of this neurological disease."

Dimebon Significantly Improved Activities of Daily Living at Both Six Mont
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SOURCE Medivation, Inc.
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