Navigation Links
Medivation Announces Presentation of Positive MDV3100 Clinical Data in Castration-Resistant Prostate Cancer Patients at 44th ASCO Annual Meeting
Date:6/2/2008

who have failed standard hormonal therapies. The dose-expansion study has enrolled 84 patients in three cohorts (60, 150, 240 mg/day) to date. Dr. Scher's presentation covered PSA data from all patients who have been followed for at least 12 weeks, the standard minimum duration of observation used to assess the treatment effects of prostate cancer drugs. Of the 42 chemo-naive and 31 post-chemotherapy evaluable patients across the three dose levels, 23 patients (55 percent) and 13 patients (42 percent) showed PSA declines greater than 50 percent at week 12 compared to baseline, respectively. Of the 28 evaluable patients from the 240 mg/day dose group of the trial, eight patients (29 percent) experienced a decline in PSA levels of greater than 90 percent compared to 9 percent and 13 percent in the 60 mg/day and 150 mg/day dose groups, respectively.

The number of CTC in a blood sample from a prostate cancer patient can indicate prognosis; patients with higher CTC counts (greater than or equal to five) are thought to have less favorable prognoses. MDV3100 treatment preserved favorable prognosis CTC counts below five in 92 percent of patients in the 60 and 150 mg/day dose groups and converted CTC counts from unfavorable to favorable prognoses in 33 percent of patients in the 60 mg/day dose group and in 56 percent of patients in the 150 mg/day dose group, respectively.

Importantly, radiographic data from both the 60 mg/day and 150 mg/day dosing cohorts showed stabilization of disease through 12 weeks of treatment. Of the 15 evaluable patients with soft tissue disease, 12 patients (80 percent) had stabilization of disease. Prior to enrollment in this study, all these patients had progressive disease despite standard-of-care hormonal therapies, and in roughly half the patients, also chemotherapy. As opposed to most previous studies in CRPC that have used the RECIST criteria to define evaluable patients and assess radiographic changes, the MDV3100 data were ana
'/>"/>

SOURCE Medivation, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Medivation Announces Presentation of MDV3100 Clinical Data in Patients With Castration-Resistant Prostate Cancer at 44th American Society of Clinical Oncology Annual Meeting
2. Medivations Dimebon(TM) Significantly Improved Thinking and Memory in Alzheimers Disease Patients Over One Year
3. Medivations Dimebon(TM) Significantly Improved Daily Function in Alzheimers Disease Patients, Resulting in Reduced Need for Caregiver Assistance
4. Medivations Dimebon(TM) Stabilizes Behavioral Symptoms in Alzheimers Disease Patients, Resulting in Reduced Caregiver Distress
5. Medivations MDV3100 Demonstrates Substantial PSA Reductions in First Patient Groups Treated in Phase 1-2 Hormone Refractory Prostate Cancer Trial
6. Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois
7. IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients
8. Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)
9. CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma
10. Poniard Announces Positive Efficacy and Safety Data From Phase 1 Trial of Picoplatin in Multiple Tumor Types Including Ovarian Cancer
11. Poniard Announces Positive Preliminary Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in First-Line Treatment of Colorectal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... Oct. 30, 2014  Misonix, Inc. (NASDAQ: ... designs, manufactures and markets innovative therapeutic ultrasonic instruments for ... that it will report financial results for the first ... The Company has scheduled a conference call that same ... to review the results. Interested parties ...
(Date:10/30/2014)... , Oct. 30, 2014 Boston Scientific ... participate in the 2014 Credit Suisse Annual Healthcare Conference ... , AZ.  Dan Brennan , executive vice ... about the company beginning at approximately 8:00 a.m. PT ... A live webcast of the presentation and question and ...
(Date:10/30/2014)... -- Nektar Therapeutics (Nasdaq: NKTR ) will announce ... 30, 2014 on Thursday, November 6, 2014, after the ... president and chief executive officer, will host a conference ... Eastern Time (ET)/2:00 p.m. Pacific Time (PT). ... of the conference call can be accessed through a ...
Breaking Medicine Technology:Misonix, Inc. To Report First Quarter Fiscal Year 2015 Financial Results On Thursday, November 6, 2014 2Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2Nektar to Announce Financial Results for the Third Quarter 2014 on Thursday, November 6, 2014, After Close of U.S.-Based Financial Markets 2
... Aug. 20, 2011 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc. (NASDAQ: ... leading China-based biotechnology company focused on researching, developing, ... the annual general meeting of shareholders of 3SBio ... at 10:00 a.m., Shenyang time, at our executive ...
... As Medicare expands a controversial "competitive" bidding program for home ... Congress have gone on record to oppose that program citing ... and impact on local jobs. "There,s a reason ... 244 economists and auction experts , and 145 members ...
Cached Medicine Technology:3SBio Inc. to Hold 2011 Annual General Meeting on September 20, 2011 2Myths and Realities About Medicare's Competitive Bidding Program for Home Medical Equipment and Services 2Myths and Realities About Medicare's Competitive Bidding Program for Home Medical Equipment and Services 3Myths and Realities About Medicare's Competitive Bidding Program for Home Medical Equipment and Services 4Myths and Realities About Medicare's Competitive Bidding Program for Home Medical Equipment and Services 5
(Date:10/30/2014)... treatments for injuries and damage to the joints, including ... is a hard material that caps the ends of ... biomedical engineers, exploring ways to toughen up engineered cartilage ... new developments this week in the journal Proceedings ... problem with engineered tissue is that the mechanical properties ...
(Date:10/30/2014)... Nutrition Leaders, a popular online retailer ... and more, is currently hosting a sweepstakes on its ... is open to U.S. residents age 18 and over, ... One lucky winner will then be selected at random ... card to NutritionLeaders.com. , Nutrition Leaders’ managing director Kimba ...
(Date:10/30/2014)... Portland, OR (PRWEB) October 30, 2014 ... law firm Hodgkinson Street LLC announces new branding ... Hodgkinson Street Mepham . After David Mepham’s promotion ... revitalizes their brand and website to include Mepham’s name ... leading medical malpractice and mediation firm, the decision to ...
(Date:10/30/2014)... Tara Haelle ... News) -- More than 100 genes have been identified ... studies report. And researchers say they are on ... that may contribute to the disorder. Autism spectrum ... communication and social difficulties and repetitive behaviors. An estimated ...
(Date:10/30/2014)... 30, 2014 Global prebiotics market is ... to a new study by Grand View Research, Inc. ... for sugar and fat free products owing to increased ... for prebiotics over the forecast period. , View full ... Food & beverage was the largest application segment with ...
Breaking Medicine News(10 mins):Health News:Making lab-grown tissues stronger 2Health News:Nutrition Leaders Announces Gift Card Sweepstakes 2Health News:Hodgkinson Street Mepham Rebrands 2Health News:Discovery of 100-Plus Genes Tied to Autism May Improve Treatments 2Health News:Discovery of 100-Plus Genes Tied to Autism May Improve Treatments 3Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 2Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 3Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 4Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 5
... a dangerous heart arrhythmia, study finds , THURSDAY, Dec. ... rapid heartbeat called ventricular tachycardia often get implantable cardiac ... study suggests that they will have fewer recurrences of ... ablation before they receive the device. , Reporting Dec. ...
... , REDMOND, Wash., Dec. 31 It,s a fact: each ... from concerned family members looking for help and answers as to ... assistance. The surge comes post holiday, a time when adult children ... parents and family members. Aegis Living, a national leader in senior ...
... genetic puzzle to try to save the mammals , THURSDAY, ... understanding of an outbreak of cancerous tumors that is killing ... , Devil facial tumor disease, a kind of cancer that,s ... contact, is one of only two types of cancer known ...
... , , WESTON, Fla., Dec. ... (the Company) annual meeting of shareholders on December 28, 2009 ... As there were not sufficient shares present in person or by ... Meeting, the Company adjourned the Annual Meeting in order to permit ...
... boom could strain resources with not just more but sicker ... getting older, and experts say the nation,s health-care system is ... The oldest members of the 78-million-strong baby-boom generation are about ... proportion of U.S. residents older than 65 will double, according ...
... , MISSION, Kan., ... subsidy extension into law on Dec. 19, 2009. With this extension, ... and adjust administrative procedures. To smooth the transition, COBRAGuard Inc. is ... Central Time. The Webinar is entitled, "How to Get it Right ...
Cached Medicine News:Health News:Procedure Boosts Outcomes in Implantable Defibrillator Patients 2Health News:After the Holidays Families Recognize Changing Needs of Aging Parents and Loved Ones 2Health News:After the Holidays Families Recognize Changing Needs of Aging Parents and Loved Ones 3Health News:Clues to Cancer That Could Wipe Out Tasmanian Devils 2Health News:American Scientific Resources 2009 Annual Meeting of Shareholders Adjourned 2Health News:As U.S. Ages, Health Care May Need to Change 2Health News:As U.S. Ages, Health Care May Need to Change 3Health News:COBRAGuard Offers Free Action Plan Webinar to Assist Employers with COBRA Subsidy Extension 2Health News:COBRAGuard Offers Free Action Plan Webinar to Assist Employers with COBRA Subsidy Extension 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: