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Medivation Announces Positive Top-Line Results From Phase 2 Dimebon Study in Huntington's Disease
Date:7/7/2008

- Dimebon Significantly Improves Cognition and is Well Tolerated in

Huntington's Disease Patients -

- Findings Warrant Further Development in Huntington's Disease -

- Conference Call Scheduled for Today at 5:00 p.m. EDT -

SAN FRANCISCO, July 7 /PRNewswire-FirstCall/ -- Medivation, Inc. (Nasdaq: MDVN) today announced top-line results of a Phase 2 study showing that its investigational drug Dimebon(TM) significantly improved cognitive function in patients with mild-to-moderate Huntington's disease (HD). Cognitive function was significantly improved over placebo (p=0.03) as measured by the Mini-Mental State Examination (MMSE), the cognition scale most widely used by clinicians to assess patients with neurodegenerative diseases. Dimebon-treated patients also demonstrated favorable results on the behavioral component of the United Huntington's Disease Rating Scale (UHDRS), a composite scale measuring several components of HD, but these results did not reach statistical significance.

Dimebon was very well tolerated in this trial. The overall incidence of adverse events was lower in the Dimebon group than in the placebo group, an unusual finding in a clinical study of any drug. This result is consistent with a similar finding from the first pivotal Alzheimer's disease trial in which Dimebon-treated patients had significantly fewer serious adverse events after one year of treatment. Of particular note, Huntington's disease patients treated with Dimebon had fewer falls (9%), a common problem in this patient population that often results in injury and associated health care costs, than did patients on placebo (16%). The most common adverse event in the Dimebon group was headache, which occur
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SOURCE Medivation, Inc.
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