Navigation Links
Medco Research Institute Study Shows Some Patients Discontinue New Anticoagulant Drug Early, Which May Increase Stroke Risk
Date:11/14/2011

ORLANDO, Fla., Nov. 14, 2011 /PRNewswire/ -- Patients using Pradaxa (dabigatran), a new blood thinner aimed at preventing stroke and blood clots, failed to remain on the treatment 17 percent of the time after the first four months, according to a study presented at the American Heart Association's Scientific Sessions.

(Logo: http://photos.prnewswire.com/prnh/20100609/MEDCOLOGO)

The research conducted by Medco Research Institute™, a subsidiary of Medco Health Solutions, Inc. (NYSE: MHS), is the first real-world study to examine dabigatran's use since its introduction last year.  Dabigatran is an alternative to the popular blood-thinner warfarin, a drug dating to the 1950s and sold under the brand names Coumadin® and Jantoven®.  Warfarin can be difficult to dose properly and patients need to be monitored closely to prevent bleeds or blood clots.  The study showed that warfarin therapy was prescribed in 71 percent of patients during the prior 6 months to starting dabigatran treatment, suggesting that prescribers are adopting dabigatran as an alternative to warfarin.

"Dabigatran is indicated to prevent serious health conditions such as stroke and systemic embolism in patients with nonvalvular atrial fibrillation, so we wanted to examine how people are using the medication, and more importantly, if patients are staying on this vital therapy," said Dr. Eric Stanek, vice president of research at Medco.  "We are seeing a sizable proportion of patients drop off treatment in a fairly short time.  This is a twice-daily drug and stroke prevention outcomes may be particularly sensitive to how consistently patients take it, pointing to a need and opportunity to provide dedicated and proactive patient support."

"We have begun to engage patients with gaps in their dabigatran therapy, and our specialist pharmacists help them get back to taking it as prescribed or notify their doctors to consider an appropriate alternative," said Dr. Donald Pittman, national practice leader of the Medco Cardiovascular Therapeutic Resource Center®. "Our data show the importance of actively monitoring the course of therapy in patients taking dabigatran. No matter how effective it can be at preventing a stroke, it won't work if patients don't take it, which means doctors and pharmacists need to regularly monitor persistence and discuss adherence to therapy with dabigatran."


Researchers also found higher associated short-term rates of hospitalization for stroke and systemic embolism and bleeding than was reported in a previous clinical trial with dabigatran in September 2009; the Randomized Evaluation of Long-Term Anticoagulation Therapy study (RE-LY) was a head-to-head study of the drug versus warfarin.  The RE-LY study found patients who received dabigatran 150 mg twice a day had a similar bleeding risk, but a lower incidence of stroke and blood clots compared to warfarin.  Dabigatran is usually prescribed at 150 mg twice a day; however, some patients with reduced kidney function should receive 75 mg twice a day.

"It's not unusual to see a difference in event rates between clinical trials and the 'real-world' experience when it comes to newly-marketed prescription drugs," Stanek said.  "This further highlights the need for continuous surveillance of anticoagulant drug effectiveness and safety, as well as the opportunity to conduct longer-term comparative outcome studies on warfarin and alternative agents such as dabigatran and rivaroxaban."  Stanek added "It will be particularly interesting to further explore the role of warfarin pharmagenomics in such a comparison, and we have plans underway to do just that."

Study Details

Medco examined de-identified prescription claims between Nov. 1, 2010 and Dec. 31, 2010 for 1,143 patients prescribed dabigatran for up to four months of follow-up. Medical diagnoses were determined by de-identified medical claims.  Demographic and clinical characteristics of patients, prescriber specialty, 4-month persistence to dabigatran therapy, and hospitalization for stroke or systemic embolism and bleeding were assessed.  Persistence to the medication at 120 days was calculated allowing a 45-day supply gap.  The average patient was 73 years old, and was using nine chronic medications.  Medical history over the 12 months prior to initiating dabigatran included: stroke (10 percent); venous thromboembolism (5 percent); pulmonary embolism (5 percent); valve replacement (2 percent).  About 19 percent had a prior history of bleeding, and 13 percent did not have a medical claims history of atrial fibrillation.  Patients received their dabigatran prescriptions mainly through retail pharmacies.  Overall, cardiologists were the highest prescribers (62 percent), followed-by primary care physicians (23 percent).  

The study was presented at the American Heart Association Scientific Sessions 2011 in Orlando, FL.  Stanek, Barnabie C. Agatep, Vivian Herrera, Gosia Hawk, Bruce J. Schrader, Pittman, Felix W. Frueh, and Scott L. Charland (senior investigator) authored the study.

About Medco Research Institute

Medco Research Institute® is an evidence-based research organization focused solely on novel research, analytics and new discoveries that close the gap between scientific discovery and medical practice for improved patient outcomes and lower overall healthcare costs. More information about the Medco Research Institute's peer-reviewed research can be found at www.medcoresearch.com.

About Medco

Medco Health Solutions, Inc. (NYSE: MHS) is pioneering the world's most advanced pharmacy® and its clinical research and innovations are part of Medco making medicine smarter™ for approximately 65 million members.

With more than 20,000 employees worldwide dedicated to improving patient health and reducing costs for a wide range of public and private sector clients, and 2010 revenues of nearly $66 billion, Medco ranks 34th on the 2011 Fortune 500 list and is named among the world's most innovative, most admired and most trustworthy companies.

For more information, go to http://www.medcohealth.com.

This press release contains "forward-looking statements" as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements involve risks and uncertainties that may cause results to differ materially from those set forth in the statements. No forward-looking statement can be guaranteed, and actual results may differ materially from those projected. We undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements in this press release should be evaluated together with the risks and uncertainties that affect our business, particularly those mentioned in the Risk Factors section of the Company's Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission.


'/>"/>
SOURCE Medco Health Solutions, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Nationwide Coalition Joins Reps. Courtney & Marino Outside U.S. Capitol To Oppose Express Scripts/Medco Merger
2. Lawmakers, Pharmacists Rally Against Express Scripts-Medco Merger Proposal at U.S. Capitol
3. Nationwide Coalition Issues Call To Action To Stop Express Scripts/Medco Merger
4. Nationwide Coalition Opposes Express Scripts/Medco Merger
5. Medco, Quest Diagnostics Personalized Medicine Study Yields Additional Clues about Patient Engagement
6. Medco Wins 2011 URAC Award for Best Practices in Health Care Consumer Empowerment and Protection
7. Merger of Express Scripts and Medco Health Solutions Will Address the Bipartisan Mandate for Safer, More Affordable, Higher Quality Healthcare
8. Polymedco, Inc., and Cardinal Health Sign Agreement for Distribution of Oncologic Diagnostic Test Kits to Acute Care Market
9. Polymedco Announces Publication in Epidemiologic Reviews
10. Prometheus and the Medco Research Institute® to Evaluate the Use of Prometheus Thiopurine Metabolite Testing for Optimizing Treatment of Inflammatory Bowel Disease Patients
11. Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
Breaking Medicine News(10 mins):