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Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting
Date:4/15/2008

ipilimumab administered on the first day of the

28-day cycle for up to four cycles. Ipilimumab dosing initially ranged

from 0.5 mg/kg to 3 mg/kg. Additional patients are now being treated

with higher doses (5 mg/kg and 10 mg/kg) of ipilimumab. The treatment

combination was generally well-tolerated. Adverse events associated

with ipilimumab treatment are consistent with data previously reported

from this study and from other clinical trials of ipilimumab.

About Medarex

Medarex is a biopharmaceutical company focused on the discovery, development and potential commercialization of fully human antibody-based therapeutics to treat life-threatening and debilitating diseases, including cancer, inflammation, autoimmune disorders and infectious diseases. Medarex applies its UltiMAb(R) technology and product development and clinical manufacturing experience to generate, support and potentially commercialize a broad range of fully human antibody product candidates for itself and its partners. More than 40 of these therapeutic product candidates derived from Medarex technology are in human clinical testing or have had INDs submitted for such trials, with seven of the most advanced product candidates currently in Phase 3 clinical trials or the subject of regulatory applications for marketing authorization. Medarex is committed to building value by developing a diverse pipeline of antibody products to address the world's unmet healthcare needs. For more information about Medarex, visit its website at http://www.medarex.com.

Medarex Statement on Cautionary Factors

Except for the historical information presented herein, matters discussed herein relating to the interim data from ongoing ipilimumab combination Phase 1 studies may constitute forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to
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SOURCE Medarex, Inc.
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