Navigation Links
Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting
Date:4/15/2008

M Santegoets, Ph.D., from the Department of Medical Oncology

and Pathology of Vrije Universiteit Medical Center located in

Amsterdam, Netherlands. The data suggested an ipilimumab dose-related

association with increased T-cell activation, as well as associated

anti-tumor activity from the initial 12 patients that was previously

reported at the June 2007 American Society of Clinical Oncology (ASCO)

meeting.

In the Phase 1 clinical trial, 28 patients with metastatic HRPC have

been enrolled, including 12 patients in the dose-escalation cohort

(0.3, 1, 3 or 5 mg/kg ipilimumab) and 16 patients in the expansion

cohort (3 mg/kg ipilimumab). The dose of GVAX immunotherapy for

prostate cancer used in this combination trial is comparable to that

currently being evaluated in Cell Genesys' ongoing Phase 3 program. The

treatment combination was generally well-tolerated. Adverse events

associated with this regimen are consistent with data previously

reported from this study.

-- "CTLA-4 blockade for hormone refractory prostate cancer: dose-dependent

induction of CD8+ T cell activation and clinical responses" (Abstract

#2539)

Preliminary data from an ongoing Phase 1 study of escalating doses of

ipilimumab in combination with GM-CSF (sargramostim) were presented by

Lawrence Fong, Ph.D., from the University of California, San Francisco,

San Francisco. Of the six patients treated at 3 mg/kg ipilimumab, three

experienced confirmed decreases in prostate-specific antigen (PSA)

serum levels of over 50%, and one of these patients experienced a

partial response in hepatic metastases.

In the Phase 1 clinical trial, 26 patients with HRPC received treatment

with a 28-day cycle of daily doses of 250 mg/m2 of GM-CSF for 14 days

in combination with
'/>"/>

SOURCE Medarex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Medarex Announces Allowance of Investigational New Drug Applications for Wholly Owned Fully Human Anti-CD19 Antibody, MDX-1342
2. Medarex to Receive Milestone Payment from Amgen
3. Medarex Announces Ipilimumab Program Continues to Move Forward
4. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
5. Spherix Reports Second Quarter Earnings
6. Tapestry Reports Second Quarter 2007 Results
7. Callisto Reports on Second-Quarter 2007 Milestones
8. ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
9. Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs
10. Paper in International Journal of Oncology Reports Alfacells ONCONASE(R) Suppresses Intracellular Oxidative Stress
11. TAXUS WOMAN Study Reports Positive Clinical Outcomes for the TAXUS(R) Drug-eluting Stent in Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... VIEW, California , 20 de octubre de ... líder en el campo de la pulmonología intervencional, ... su Estudio RENEW, casi 3 meses antes de ... fundamental de exención de dispositivo de investigación (IDE) ... Medicamentos) para el sistema de espiral de reducción ...
(Date:10/20/2014)... SAN DIEGO , Oct. 20, 2014   BioNano ... the Irys system: the ability to collect human data at ... on a single chip.  This new capability was established and ... for the Irys TM System and will ... next two months. BioNano will be showcasing this advancement at ...
(Date:10/20/2014)...   Mary,s Medicinals today announced that its ... Sponsor of Operation Grow4Vets , a national, nonpartisan ... and services to assist them in living with injuries ... , An ever-increasing number of medical studies ... treatment for pain, Post-traumatic Stress Disorder (PTSD) and Traumatic ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3BioNano Genomics Announces One Human : One Chip : One Day 2BioNano Genomics Announces One Human : One Chip : One Day 3Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 3
... 2011 Reportlinker.com announces that a new market research report ... In Vitro Diagnostics Market http://www.reportlinker.com/p0470752/World-In-Vitro-Diagnostics-Market.html ... through 2014 The Freedonia Group projects world ... annually to nearly $68 billion in 2014. Based on the ...
... Reportlinker.com announces that a new market research report ... European Markets for Patient Monitoring Devices and Equipment ... In 2010, the European patient monitoring ... 2008 and 2009. This mature market is expected ...
Cached Medicine Technology:Reportlinker Adds World In Vitro Diagnostics Market 2Reportlinker Adds World In Vitro Diagnostics Market 3Reportlinker Adds World In Vitro Diagnostics Market 4Reportlinker Adds World In Vitro Diagnostics Market 5Reportlinker Adds World In Vitro Diagnostics Market 6Reportlinker Adds World In Vitro Diagnostics Market 7Reportlinker Adds World In Vitro Diagnostics Market 8Reportlinker Adds World In Vitro Diagnostics Market 9Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 2Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 3Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 4Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 5Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 6Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 7Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 8Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 9Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 10Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 11Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 12Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 13Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 14Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 15Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 16Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 17Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 18Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 19Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 20Reportlinker Adds European Markets for Patient Monitoring Devices and Equipment 2011(15 Countries) 21
(Date:10/20/2014)... (PRWEB) October 20, 2014 Based ... are the only imaging assays capable of determining ... single test.  With these three dimensions of high-resolution ... to detect the widest range of disease-causing genetic ... missed by other genomic tools, including today’s advanced ...
(Date:10/20/2014)... 2014 Unveiled at the Sept. 18 board ... conservatively estimates member hospital ROI on membership dues at 12.5. ... Center provides $12.50 in value to member hospitals. The calculation ... Member Dues)/Member Dues. , “This is the first time ... we think the methodology is really sound,” said Bill ...
(Date:10/20/2014)... Houston, Texas (PRWEB) October 20, 2014 ... invited to present the key elements of his innovative ... visiting professor to plastic surgery residents and faculty at ... (UTMB) , where he, too, was once a medical ... of the largest private cosmetic plastic surgery practices in ...
(Date:10/19/2014)... October 20, 2014 The leading ... ( http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the best ... platforms for those who want to buy high ... time. , The IT manager of Top10BestSEOHosting.com says, ... most recommended suppliers for everyone. A lot of ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 This ... for Partial Seizure, complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ... news and press releases. It also reviews key ... Seizure and special features on late-stage and discontinued ...
Breaking Medicine News(10 mins):Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Plastic Surgeon Patronella Presents Artistically-Inspired Tummy Tuck Method to Future Generation of Plastic Surgeons in Texas 2Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 4
... simple diagnostic modality can help predict the outcome of ... It can predict which patient would benefit from the ... valuable study can be found in the latest issue ... physicians identify factors that cause specific symptoms by demonstrating ...
... prescription drugs in the filtered and recycled wastewater at ... dangerous effects this water might have in the future. ... antibiotics, antipsychotics, birth-control hormones, Viagra and Valium have been ... the wastewater is because people flush them down their ...
... Boston, a surgery was conducted on a baby inside the womb. ... the womb. // She was discharged on Friday after the successful ... a heart defect called hypoplastic left heart syndrome (HLHS) inside the ... in the developing fetus on November 7, 2005. ,She ...
... services in a hospital at Brisbane a patient had to ... was attacked and was in serious condition, attention could not ... Caboolture Hospital, where emergency services are scarce due to shortage ... presently operational from 8am to 6pm every day. ...
... announced that it intends to fast track its inhaled insulin ... Food and Drug Administration // and the European Commission ... Sanofi-Aventis and Nektar Therapeutics. ,It is a relatively ... or syringes are needed. "Until today, patients with diabetes who ...
... successfully reached the Vinson Massif summit, one of Antarctica's ... and was successfully completed on January 19th after eight ... was a strong, healthy athlete who was later diagnosed ... of the disease he lost 80 pounds and his ...
Cached Medicine News:Health News:SPECT Can Help Predict Treatment Outcome In Patients With Low Back Pain 2Health News:Medications Detected In Recycled Water In Los Angeles 2Health News:Baby Underwent A Heart Surgery Inside The Womb 2Health News:Crohn's Patient Robert Hill’s greatest achievemen 2
Toothed grasping forcep....
Bateman pituitary forceps, round cup, 5 mm bite, fenestrated crocodile jaws, 150 mm effective....
Micro cup pituitary forceps, semi-malleable shafts....
Bayonet Kerrison Rongeur, ceramic ejector, 9.5 length 40 Fwd, 6.5 working length 165 mm....
Medicine Products: