Navigation Links
Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City
Date:7/10/2008

ntibody with enhanced antibody effector function that targets CD70, a member of the TNF family that is highly expressed on multiple cancers, including renal cell carcinoma, lymphoma and glioblastoma. CD70 expression on activated lymphocytes may also be implicated in autoimmune diseases. Data from the ongoing Phase 1 trial in clear cell renal carcinoma is expected in 2009. Additional opportunities include the expected initiation of a Phase 1 trial of MDX-1411 in lymphomas in 2008, as well as an anti-CD70 antibody-drug conjugate program.

-- MDX-1203 targets the CD70 molecule expressed on multiple cancers and is expected to be the first Medarex antibody-drug conjugate candidate to enter clinical development in 2008/early 2009.

"We are making great strides in developing potentially important therapeutics to address a wide range of cancer and inflammatory diseases," Geoffrey M. Nichol, M.B.Ch.B., Senior Vice President of Product Development at Medarex. "We continue to progress towards proof-of-concept for multiple programs and look forward to advancing our most promising candidates towards market approval."

Research and Development

Medarex has enhanced its core UltiMAb(R) antibody platform with a suite of technologies that optimize or enhance the therapeutic activity of antibodies. One important technology expansion is the company's proprietary antibody-drug conjugate (ADC) platform. Medarex believes that its ADC technology overcomes many of the key development challenges of drug conjugates, including issues of linker stability, potency and multi-drug resistance while maintaining a wide therapeutic window with minimal toxicity. Coupled with cutting-edge antibody technologies, Medarex's sophisticated drug development infrastructure and decision-making processes engage expertise in the areas of science, clinical development and market research to maximize efficiency, increase productivity, augment the quality of our antibody drug development eff
'/>"/>

SOURCE Medarex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Medarex Announces Allowance of Investigational New Drug Applications for Wholly Owned Fully Human Anti-CD19 Antibody, MDX-1342
2. Medarex to Receive Milestone Payment from Amgen
3. Medarex Announces Ipilimumab Program Continues to Move Forward
4. Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting
5. Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology
6. Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis
7. Genta Incorporated Announces Second Quarter 2007 Financial Results and Corporate Highlights
8. Five-Year Data From Taxus II Clinical Trial Highlights Safety and Efficacy of Taxus(R) Stent Compared to Bare-Metal Stent
9. President Clinton Highlights MWW Group at the 2007 Clinton Global Initiative for its Stop Neglected Tropical Disease Campaign
10. Genaera Corporation Provides Highlights of Positive Phase 1 Trodusquemine (MSI-1436) Data from the North American Association for the Study of Obesity Annual Meeting
11. Schering-Plough Highlights PEGINTRON(TM) Clinical Data Presentations at the American Association for the Study of Liver Diseases (AASLD) 2007 Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... NEW YORK , March 27, 2015 ... in Santa Ana, California is a ... market for which is estimated at $22 billion in the ... includes the use of FDA-approved Naltrexone in a specially compounded ... (excluding Australia and New ...
(Date:3/27/2015)... MISSISSAUGA, ON , March 27, 2015 /CNW/ - ... an advanced medical technologies company, today announced the issuance ... independent directors of the Company and an aggregate of ... Company. The stock options will vest over three years ... years at an exercise price of $1.40 per stock ...
(Date:3/27/2015)... March 27, 2015 /PRNewswire/ - Medicure Inc. (the "Company") ... has approved the grant of an aggregate of 236,070 ... and consultants of the Company pursuant to the Company,s ... to expire on the tenth anniversary of the date ... third anniversary of the date of grant and 50,000 ...
Breaking Medicine Technology:Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2Covalon Announces Issuance of Stock Options 2
(Date:3/28/2015)... Tucson, AZ (PRWEB) March 28, 2015 Coffee ... could also help protect you from gum disease, researchers have ... protected against gum disease. , Coffee contains antioxidants. Antioxidants fight ... is the question researchers at Boston Univ. Henry M. Goldman ... published in the August 2014 issue of the Journal of ...
(Date:3/28/2015)... March 28, 2015 Take a bite ... kicks into action. Acids tumble into the stomach, ready ... faulty valve-like structure lets these acids run amok, triggering ... extremely common symptom. More than 60 million Americans have ... examine where heartburn starts, and how it can be ...
(Date:3/28/2015)... March 28, 2015 The California-based leading ... for every customer shopping on UniWigs during the Easter ... be a big promotion on April Fools’ Day. , ... is just around the corner. Easter Festival, with religious ... is a major holiday after Christmas. The best wig ...
(Date:3/28/2015)... New York, NY (PRWEB) March 28, 2015 ... 2015 highlighted a problem which could prove critical to ... Why system testing, a critical aspect of data security, ... payment card industry data security report, every major category ... vulnerability scanning and penetration testing. “With all the craziness ...
(Date:3/28/2015)... Las Vegas, NV (PRWEB) March 28, 2015 ... surgery experiences re-injury, according to research presented today at ... ) Specialty Day. The study examined the long term ... younger. , “We examined survey data from 242 ... noted lead author Justin P. Roe, MBBS, FRACS, from ...
Breaking Medicine News(10 mins):Health News:New Research Impliments Coffee May Help Fight Gum Disease and Increasing Benefits With Tylers Coffee 2Health News:Bypass Your Heartburn Worries This Easter With Tylers Coffee 2Health News:UniWigs Is Sending Out Mysterious Gifts During the Easter Holidays 2Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 2Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 3Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 4Health News:Young Athletes at Greater Risk for Re-Injury after ACL Surgery 2
... against infection, study shows , WEDNESDAY, June 17 (HealthDay ... emphysema also defends the lungs against bacterial infection, a ... the only thing macrophage elastase, matrix metalloproteinase-12 (MMP-12), did ... destruction seen in emphysema patients. , "But we found ...
... ... provider customers in discussions about healthcare reform, the importance of Medicare to their business ... healthcare objectives. , ... Stamford, CT (Vocus) June 18, 2009 -- IVANS, Inc. has been regularly ...
... Professional Launches Exclusive Product Solution With Microban Antimicrobial Protection to ... Ga., June 17 If you thought a toilet seat ... again. , , According to new research ... of Arizona , the average toilet paper dispenser has more ...
... LONDON, June 17 MediciGlobal, a leading ... Distinction in The 2009 Communicator Awards from ... Awards is the leading international awards program honouring creative ... won awards on behalf of three global pharmaceutical clients ...
... quality improvement and affordable coverage for all Americans , ... Majority Leaders Howard Baker, Tom Daschle and Bob Dole, ... today released a bipartisan, budget-neutral framework for comprehensive health ... health coverage. The Leaders, Project on the State of ...
... Across North America , , THOUSAND OAKS, Calif., ... today announced the 34 science teachers in the United States (U.S.), ... Amgen Award for Science Teaching Excellence. The award recognizes teachers ... impact on the learning and interest of the future generation of ...
Cached Medicine News:Health News:Lung Enzyme Both Friend and Foe 2Health News:IVANS Hit Experts Available To Discuss the Dept. of HHS Recommendation Of “Meaningful Use” and How Potential Tighter Standards Will Impact the Provider Community 2Health News:IVANS Hit Experts Available To Discuss the Dept. of HHS Recommendation Of “Meaningful Use” and How Potential Tighter Standards Will Impact the Provider Community 3Health News:Research from Dr. Charles Gerba Finds Average Toilet Paper & Towel Dispensers Have More Bacteria Than Average Toilet Seat 2Health News:Research from Dr. Charles Gerba Finds Average Toilet Paper & Towel Dispensers Have More Bacteria Than Average Toilet Seat 3Health News:MediciGlobal Wins Four International 2009 Communications Awards for Patient Recruitment and Retention 2Health News:Former Senate Majority Leaders Baker, Daschle and Dole Release Bipartisan Framework for Comprehensive Health Reform 2Health News:Former Senate Majority Leaders Baker, Daschle and Dole Release Bipartisan Framework for Comprehensive Health Reform 3Health News:Former Senate Majority Leaders Baker, Daschle and Dole Release Bipartisan Framework for Comprehensive Health Reform 4Health News:34 Outstanding Teachers and Schools Receive $10,000 Amgen Award for Science Teaching Excellence 2Health News:34 Outstanding Teachers and Schools Receive $10,000 Amgen Award for Science Teaching Excellence 3Health News:34 Outstanding Teachers and Schools Receive $10,000 Amgen Award for Science Teaching Excellence 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: