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Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City
Date:7/10/2008

ny's scientific and commercial vision, clinical development plans to proof-of-concept, and development milestones of select programs in clinical development. Some of the programs discussed included the following:

-- MDX-1106 (ONO-4538) is a fully human anti-PD-1 antibody in development with Ono Pharmaceuticals, Inc. for solid tumors. Preliminary data of anti- tumor activity in multiple tumor types from an ongoing Phase 1 trial were previously reported at a recent medical conference. A multi-dose Phase 2 study in solid tumors is expected to begin in 2008. A separate Phase 1 trial for hepatitis C viral infection is ongoing, with data expected in 2009.

-- MDX-1100 is a fully human antibody that targets IP-10, a chemokine that promotes the recruitment of pro-inflammatory cells that can cause tissue damage in rheumatoid arthritis and inflammatory bowel diseases. MDX-1100 represents a breakthrough mechanism of action for inflammatory disease and is being investigated in separate Phase 2 proof-of-concept trials for ulcerative colitis and rheumatoid arthritis. Interim data from these trials are expected in 2009.

-- MDX-1401 is a fully human antibody that targets CD30, a member of the TNF family expressed on CD30-positive lymphomas, including Hodgkin's lymphoma. MDX-1401 is a second-generation antibody enhanced for improved antibody effector function over the parental anti-CD30 antibody, MDX-060. Preliminary data from an ongoing Phase 1 trial of MDX-1401 is expected in 2008 at a medical conference, with final data expected in 2009.

-- MDX-1342 is a fully human antibody with enhanced antibody effector function that selectively binds to CD19, a molecule expressed on a broad range of B-cell malignancies. MDX-1342 also induces the depletion and elimination of B-cells for inflammatory disease indications. Phase 1 trials in chronic lymphocytic leukemia and rheumatoid arthritis are ongoing with data expected in 2009.

-- MDX-1411 is a fully human a
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SOURCE Medarex, Inc.
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