Navigation Links
Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis
Date:5/14/2009

Top-line data indicate statistically significant improvement in ACR20 responses over placebo

PRINCETON, N.J., May 14 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX) today announced that the MDX-1100 Phase 2 proof-of-concept trial in patients with active rheumatoid arthritis (RA) receiving methotrexate successfully met its primary endpoint. The top-line results from the recently completed 70-patient multi-center, randomized, double-blind, placebo-controlled Phase 2 trial indicated that when compared to placebo, three times the number of patients treated with 10 mg/kg of MDX-1100 every two weeks achieved at least a 20% improvement in RA signs and symptoms at 12 weeks, the primary endpoint of the study, as measured by the American College of Rheumatology (ACR) 20 measurement of response. These results were statistically significant when compared with placebo (p=0.0024). The antibody combination with methotrexate was generally safe and well-tolerated. Full results from this Phase 2 trial are planned to be presented at a future scientific meeting.

"We are greatly encouraged by this demonstration of efficacy from a well-designed and well-executed study," said Howard H. Pien, Chairman and CEO of Medarex. "These results show that by targeting the chemokine IP-10 with our MDX-1100 antibody, we may be able to offer a potentially important and novel treatment option for rheumatoid arthritis and potentially other inflammatory indications."

"Based on these positive results with a novel pro-inflammatory target, we are actively preparing for the next stage of clinical development for MDX-1100 in RA, including the potential for subcutaneous dosing," said Geoffrey M. Nichol, M.B.Ch.B., Senior Vice President of Product Development at Medarex. "We also look forward to exploring the broader potential of MDX-1100 in a range of i
'/>"/>

SOURCE Medarex, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Medarex Announces Allowance of Investigational New Drug Applications for Wholly Owned Fully Human Anti-CD19 Antibody, MDX-1342
2. Medarex to Receive Milestone Payment from Amgen
3. Medarex Announces Ipilimumab Program Continues to Move Forward
4. Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting
5. Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology
6. Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis
7. Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City
8. Medarex Announces Allowance of Investigational New Drug Application for Wholly-Owned Fully Human Anti-PD-L1 Antibody, MDX-1105
9. Medarex Announces Initiation of Phase 2 Clinical Development Program for the Treatment of Lupus
10. Medarex Announces Presentations at the 33rd Congress of the European Society for Medical Oncology
11. Medarex Receives Milestone Payment from Pfizer for Investigational New Drug Application Filing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... April 20, 2015  Johnson & Johnson (NYSE: ... business for the investment community beginning at 8:30 a.m. ... Hyatt Regency Hotel in New Brunswick, New ... Paul Stoffels , M.D., Worldwide Chairman ... , Worldwide Chairman, Pharmaceuticals will host the meeting. ...
(Date:4/20/2015)... 20, 2015 The global orthopedic ... the concerned global with analysis and forecast of revenue. ... is estimated to reach $4,918.7 million by 2019, at ... Browse through the TOC of global orthopedic braces ... the industry trends and segments, with help of various ...
(Date:4/20/2015)... 14, 2015 Research and Markets ( ... "US Proton Therapy Outlook - Market Opportunities" report ... Proton Therapy Outlook: Market Opportunities by the author, ... to almost 29 such centers by 2018, a number ... market will breach the Billion dollar mark to attain ...
Breaking Medicine Technology:Global Orthopedic Braces & Support System Market is Expected to Reach $4,918.7 Million by 2019, at a CAGR of 4.4% from 2014 to 2019 2Global Orthopedic Braces & Support System Market is Expected to Reach $4,918.7 Million by 2019, at a CAGR of 4.4% from 2014 to 2019 3United States Proton Therapy Outlook to 2018 - Market Opportunities for the $1.19 Billion Market Featuring IBA, Hitachi, Mevion Medical Systems & Varian 2United States Proton Therapy Outlook to 2018 - Market Opportunities for the $1.19 Billion Market Featuring IBA, Hitachi, Mevion Medical Systems & Varian 3
(Date:4/21/2015)... Indianapolis, IN (PRWEB) April 21, 2015 ... independent employee benefits advisory organization, is pleased to ... Partner Firm. Since 1991, Mark Kunkle and Jeff ... level of service earning the confidence of more ... service means innovative thinking, strategic planning, dedicated stewardship, ...
(Date:4/21/2015)... Nashville, Tenn. – Radsource, a leader ... Archiving and Communication Systems (PACS), has expanded its ... the first quarter of 2015. , Kentucky Breast ... and Lowcountry Orthopaedics & Sports Medicine (Charleston, SC) ... services. Mt. San Rafael Hospital (Trinidad, CO) will ...
(Date:4/21/2015)... Washington, DC (PRWEB) April 21, 2015 ... poll released today by Clements Worldwide indicates that international ... among would-be expatriates. , The survey by Clements, a ... living and working outside of their country of citizenship, ... the availability of appropriate health care insurance overseas ...
(Date:4/21/2015)... Now, busy Diet Doc clients can bolster ... diet breakfast omelets. Like Diet Doc’s other pre-packaged ... ice and are delivered directly to their door. Patients can ... that not only appeal to the taste buds, but ensure ... with healthy, low carbohydrate meals. , One of the ...
(Date:4/21/2015)... The University of Scranton has ... Informatics to answer the growing demand for professionals ... comprehensive wellness profile for better individual, real-world care. ... and implementation of health services and systems. This ... managerial operations in the healthcare sector,” says Margarete ...
Breaking Medicine News(10 mins):Health News:Power Kunkle Benefits Consulting Is the Latest Partner Firm To Join United Benefit Advisors 2Health News:Radsource Adds 4 ProtonPACS Clients in 1st Quarter 2Health News:Potential Expatriate Retirees Fear Political Violence, International Health Insurance Coverage 2Health News:Potential Expatriate Retirees Fear Political Violence, International Health Insurance Coverage 3Health News:Diet Doc Makes Dieting for People on the Go Easier than ever before with Pre-Packaged Diet Meals, Desserts, Snacks and new Breakfast Omelets 2Health News:Diet Doc Makes Dieting for People on the Go Easier than ever before with Pre-Packaged Diet Meals, Desserts, Snacks and new Breakfast Omelets 3Health News:Diet Doc Makes Dieting for People on the Go Easier than ever before with Pre-Packaged Diet Meals, Desserts, Snacks and new Breakfast Omelets 4Health News:The University of Scranton Launches Online MS in Health Informatics 2Health News:The University of Scranton Launches Online MS in Health Informatics 3
... appears to kick start recovery in the unaffected brain hemisphere ... University of Georgia study has found. The discovery, ... the online journal PLoS ONE , occurred only because ... administrative pharmacy at the UGA College of Pharmacy, struck a ...
... HealthDay Reporter , THURSDAY, Oct. 20 (HealthDay ... have many more accidents than adults have zeroed in ... braking late, swerving abruptly and other common new-driver mistakes. ... likely and leave less time to react to hazards, ...
... have a higher burden of multiple, large-joint osteoarthritis (OA), and ... "generalized OA." African Americans were also more likely to have ... OA than Caucasians according to the findings reported today in ... American College of Rheumatology (ACR). OA is the ...
... By Jenifer Goodwin HealthDay Reporter , THURSDAY, ... falling behind on your mortgage payments hurts more than just ... with the struggle can also harm your physical and psychological ... on nearly 2,500 Americans who took part in the Health ...
... HealthDay Reporter , THURSDAY, Oct. 20 (HealthDay News) ... of food and beverage packages to make it as simple ... product really is, a new Institute of Medicine report concludes. ... there," said Ellen Wartella, chair of the IOM committee that ...
... Frequent spitting up, irritability and unexplained crying in ... frequently prescribe acid-suppressing drugs for these symptoms. However, ... of these symptoms in otherwise thriving infants, and ... Pediatrics, Dr. Eric Hassall cautions against over-diagnosis of ...
Cached Medicine News:Health News:Blood-pressure-lowering drug after stroke aids recovery, study finds 2Health News:Teen Drivers Prone to 'G-Force' Errors, Researchers Say 2Health News:Teen Drivers Prone to 'G-Force' Errors, Researchers Say 3Health News:More African-Americans burdened by osteoarthritis in multiple large joints 2Health News:Foreclosure Crisis Threatening Americans' Health: Study 2Health News:Foreclosure Crisis Threatening Americans' Health: Study 3Health News:Food Nutrition Labels Must Be Made Simpler, Experts Say 2Health News:Food Nutrition Labels Must Be Made Simpler, Experts Say 3Health News:Acid-suppressing medications may be overprescribed for infants 2Health News:Acid-suppressing medications may be overprescribed for infants 3
Multipiece PMMA IOL - Sulcus Fixation....
Hydrophilic Acrylic Intraocular Lens (Refractive and Bifocal). Anterior Chamber Lens....
Raysoft Foldable Intraocular Lens....
HAPTIBAG Hydrophilic Acrylic Lens....
Medicine Products: