Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity...(ctivity as a monotherapy and enhanced ef...),Health

Development of anti-Glypican 3 therapeutic antibodies (Abstract #1233)

Glypican-3 is a protein that has been shown to be expressed in liver cancer. A panel of fully human anti-glypican-3 antibodies was generated from which a lead candidate, MDX-1414, was selected for its high affinity, specificity, effector function and internalization properties. MDX-1414 demonstrated anti-tumor efficacy leading to significant and durable suppression of established subcutaneous tumors in a liver cancer xenograft model with no evidence of toxicity. Targeting glypican-3 with antibodies enhanced for antibody-dependent cell-mediated cytotoxicity properties, as drug-conjugates or used in combination with existing therapies, may represent a potentially important new treatment for liver cancer.

Efficacy and Toxicity of anti-mesothelin antibody drug conjugate (Abstract #3235)

Mesothelin is a glycoprotein over-expressed on mesotheliomas and other cancers, including ovarian and lung cancer, and because of its limited expression in normal tissue, it is an attractive target for an antibody-drug conjugate. In xenograft models of ovarian and lung cancer, MDX-1204, a fully human anti-mesothelin antibody-drug conjugate, demonstrated significant anti-tumor activity at doses as low as 0.3 umole/kg. In addition, the antibody-drug conjugate was well-tolerated in cynomolgous monkeys and mouse models.

The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates (Abstract #1722)

The effectiveness of a cleavable linker over a non-cleavable linker when used with MGBA-based antibody-drug conjugates was examined using fully human anti-CD70 antibody-drug conjugates. In renal cancer xe
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