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Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis
Date:5/12/2008

weeks for a total of 6 doses. All patients will have active RA while on methotrexate. The trial is expected to enroll 70 patients at multiple sites in Europe. The primary endpoint of the study is the ACR20 response, a composite endpoint that indicates a 20% improvement in RA signs and symptoms, at 12 weeks.

Medarex also announced that results from the MDX-1100 Phase 1 trials will be presented at the Digestive Disease Week (DDW) meeting, being held May 17 - 22, 2008 in San Diego. The following abstracts are expected to be the subject of presentations at the DDW 2008 conference:

-- "A Double-Blind, Placebo-Controlled, Dose-Escalation, Safety and

Pharmacokinetic Study of MDX-1100, a Fully Human Anti-CXCL10 Monoclonal

Antibody, in Healthy Subjects" (Abstract #T1145) - Poster presentation

on May 20, 2008 from 12:00 to 2:00 PM CDT.

-- "A Phase 1 Open-Label, Single-Dose, Dose-Escalation Study of MDX-1100,

a High-Affinity, Neutralizing, Fully Human IgG1k Anti-CXCL10 (IP10)

Monoclonal Antibody, in Ulcerative Colitis" (Abstract #704) - Oral

presentation on May 20, 2008 from 3:00 to 3:15 PM CDT.

-- "CXCL10 Expression and Biological Activities in Inflammatory Bowel

Disease" (Abstract #W1170) - Poster presentation on May 21, 2008 from

12:00 to 2:00 PM CDT.

These presentations support the development of MDX-1100 for the treatment of inflammatory diseases such as ulcerative colitis and rheumatoid arthritis.

About MDX-1100

MDX-1100 is a fully human antibody that targets CXCL10 (also known as IP-10), a chemokine expressed in association with multiple inflammatory disease indications such as rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis.

About Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease of the colon and is characterized by inflammation and ulceration of the lining of the colon. Sy
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SOURCE Medarex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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