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Medarex Announces Allowance of Investigational New Drug Applications for Wholly Owned Fully Human Anti-CD19 Antibody, MDX-1342
Date:12/4/2007

CD19 and MDX-1342

CD19 is a B-cell specific membrane protein that is broadly expressed during B-cell development, from the pro-B-cell to the early plasma cell stage.

Clinical studies have demonstrated that depleting monoclonal antibodies directed against CD20, another B-cell specific membrane protein that has a more restricted expression pattern than CD19 during B-cell development, are effective in treating rheumatoid arthritis and various B-cell malignancies, and show promise in treating other inflammatory diseases such as systemic lupus erythematosis and multiple sclerosis.

MDX-1342 is a fully human antibody that binds selectively to CD19 expressed on B-cells (without targeting stem cells or fully differentiated plasma cells, which lack CD19 expression) and induces the depletion and elimination of CD19-positive B-cells.

About Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia (CLL) is a cancer that affects B-cell lymphocytes, an important component of the immune system that helps the body fight infection or cancer. The American Cancer Society estimates that in 2007, approximately 15,340 new cases of chronic lymphocytic leukemia will occur in the United States, and approximately 4,500 people will die of the disease in 2007.

About Rheumatoid Arthritis

According to the American College of Rheumatology, more than two million Americans suffer from rheumatoid arthritis (RA), a chronic autoimmune disease that develops when certain cells of the immune system inappropriately attack healthy joint tissue, thereby causing swelling, inflammation and damage of joints, as well as systemic inflammation and damage of other tissues.

About Medarex

Medarex is a biopharmaceutical company focused on the discovery, development and potential commercialization of fully human antibody-based therapeutics to treat life-threatening and debilitating diseases, including cancer, inflammation, autoimmune disorders and infectio
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SOURCE Medarex, Inc.
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