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MedImmune Focused on Revolutionizing Cancer Care
Date:11/16/2010

r Institute and the American Association for Cancer Research.  These abstracts include:

  • Glioblastoma multiforme is characterized by high incidence of PDGFR-alpha expression and susceptibility to the PDGFR-alpha-specific antibody MEDI-575 in mouse tumor models – presented by Dr. Philipp Steiner, on Wednesday, November 17

  • Inhibition of PDGFR-alpha in tumor stroma with MEDI-575 enhances activity of carboplatin/  paclitaxel and delays tumor regrowth in a NSCLC xenograft model – presented by Dr. Philipp Steiner, on Wednesday, November 17

  • Phase I study of MEDI-575, a fully human monoclonal antibody targeting PDGFR-alpha in subjects with advanced solid tumors – presented by Dr. Robert Lechleider, on Thursday, November 18

  • MEDI-573, a dual IGF-1/-2 neutralizing antibody, blocks IGF-1R and IR-A signaling and maintains glucose homeostasis in a phase 1 study for advanced solid tumors –presented by Dr. Michael Menefee, on Thursday, November 18

Then in December, two MedImmune-sponsored posters are being presented at the 52nd ASH (American Society of Hematology) starting on Saturday, December 4 in Orlando, including:

  • A phase I study of moxetumomab pasudotox (CAT-8015), an anti-CD22 recombinant immunotoxin, in relapsed/ refractory hairy cell leukemia (HCL): updated results – presented by Dr. Robert Kreitman, on Sunday, December 5

  • Complete remissions in 3 of 12 patients with chemotherapy-refractory pediatric acute lymphoblastic leukemia (ALL) during phase I testing of the anti-CD22 immunotoxin moxetumomab pasudotox (CAT-8015)– presented by Dr. Alan Wayne, on Monday, December 6'/>"/>

SOURCE MedImmune
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