Navigation Links
MedImmune Advances Asthma Program with Start of a Phase 2 Trial in Europe and Australia and First U.S.-Based Clinical Trial for Antibody Targeting IL-13
Date:4/15/2008

vivo systems and Phase 1 data in mild to moderate asthmatic volunteers demonstrated the safety and tolerability of the monoclonal antibody, thus supporting its continued development.

About Interleukin-13 (IL-13)

Preclinical data has demonstrated that IL-13 plays an important role in asthma. It is one of at least 29 naturally occurring interleukins in the human body. Overexpression of IL-13 in animal models has been shown to result in many of the features associated with human asthma. IL-13 is believed to be a relevant target for treating asthma, considering its potential role in airway obstruction and in chronic airways remodeling, as seen in animal models.

Clinical Development in Asthma

MedImmune has multiple approaches in development targeting asthma. Currently, in human testing the company has antibodies targeting IL-9 (MEDI 528) and IL-13 (CAT-354), each in Phase 2 development, and an anti-IL-5 receptor (MEDI 563), which is in Phase 1 development. In addition, the company has a number of antibodies that are anticipated to be designated as drug candidates.

About Asthma

Asthma is a chronic disease of the airways that may cause wheezing, breathlessness, chest tightness and coughing. According to the U.S. Centers for Disease Control and Prevention (CDC), more than 30 million Americans reported having a history of asthma in 2003, including nine million children. About 20 million said they currently had asthma. In 2000, the CDC reported that there were more than 10 million asthma-related outpatient visits to private physician offices and hospital clinics. The National Institutes of Health (NIH) have estimated asthma-related healthcare costs in the U.S. at $14 billion annually.

About MedImmune

MedImmune strives to provide better medicines to patients, new medical options for physicians and rewarding careers to employees. Dedicated to advancing science and medicine to help people live better lives, the company is f
'/>"/>

SOURCE MedImmune
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Phase 2a Multi-Dose Study Initiated by MedImmune in Patients With Asthma to Further Expand Anti-Interleukin-9 Program
2. MedImmune Initiates Phase 2a Multi-Dose Study in Patients with Asthma
3. MedImmunes Motavizumab Reduced RSV Hospitalizations by 83 Percent Among High-Risk Native American, Full-Term Infants in Placebo-Controlled Phase 3 study
4. MedImmune Announces Phase 2 Safety Data for Anti-RSV Antibody and National RSV Surveillance Results
5. MedImmune Presents New Pharmaco-Economic Data at American Academy of Pediatrics Regarding Infants at High Risk for RSV
6. The New England Journal of Medicine Publishes First Clinical Results for MedImmunes Chitinase-like Protein YKL-40 in Patients With Asthma
7. MedImmune Initiates First Clinical Trial of Monoclonal Antibody Targeting GM-CSFR in Patients with Rheumatoid Arthritis
8. MedImmune Advances Clinical Development of Antibody Targeting Interleukin-9 in Patients with Asthma
9. Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma
10. Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs
11. Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... FRANCISCO, Calif. , Nov. 24, 2014  Rigel Pharmaceuticals, ... M. Gower is retiring from the board of directors ... and Raul Rodriguez , most recently serving as the ... of chief executive officer and join the board of directors.  ... Directors since 2005, will become chairman. Mr. Gower is expected ...
(Date:11/23/2014)...  Aurobindo Pharma USA is ... mg 100-count bottles to the consumer level. The product ... Empty capsules could result in missed dose(s) ... range from no effect, short term reduction in efficacy, ... seizures) that could be life-threatening. Aurobindo Pharma ...
(Date:11/22/2014)... Calif. , Nov. 21, 2014   Long Beach ... implants are often called the gold standard in tooth replacement ... are a stable, long-lasting way to restore and preserve smiles ... implants to replace a missing tooth or as a part ... transform the look and feel of a smile. ...
Breaking Medicine Technology:Rigel Announces Executive Management Changes 2Rigel Announces Executive Management Changes 3Aurobindo Pharma USA, Inc. Issues Voluntary Nationwide Recall of Northstar Label Gabapentin Capsules, USP 300 mg Due to Complaints of Empty Capsules 2Long Beach Dentist, Dr. Rassouli, is Now Offering Dental Implants 2
... on complex cases, facility called ,future of hospital care, ... announces the opening of the Hamon Tower, the largest expansion ... intensive care for the region,s most critically ill patients. , ... new clinical programs for ICU patients, Hamon Tower is designed ...
... IRVINE, Calif., Oct. 2 ISTA Pharmaceuticals, Inc. (Nasdaq: ... financial results after market close on November 3, 2009. In ... p.m. Eastern Time to discuss these results and provide a ... , Time: 5:00 p.m. Eastern Time , Conference call ...
Cached Medicine Technology:Hamon Tower Features Critical Care Advances, Potential for Reduced Costs 2
(Date:11/24/2014)... The Holiday Inn Westbury - Long ... Children's Association to donate various items consisting of ... other such items.The Association's program is aimed toward helping ... in nursing homes, assisted living facilities and nursing homes. ... being of seniors throughout the Long Island area. The ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 ReAdmission ... and disease management services to health plans, hospitals, ... Essette’s Medical Management software suite. ReAdmission Solutions ... in a program to reduce patients' avoidable readmissions ... Health Management, Care Management, Utilization Management, and Appeals ...
(Date:11/23/2014)... 24, 2014 iFitDress.com, a well-known wedding dress ... evening gowns . They are now offered at deeply ... will last from now to Dec. 15. The main purpose ... All the company’s high quality items are ideal options for ... large sum of money. All its new mint cocktail dresses ...
(Date:11/23/2014)... 2014 Nearly 260 testosterone lawsuits ... deep vein thrombosis and other serious cardiovascular events ... litigation (MDL) underway in the Northern District of ... documents updated on November 17th by the U.S. ... filing of 259 lawsuits against the makers of ...
(Date:11/23/2014)... 23, 2014 To show thanks to new ... collection of white evening dresses for weddings. Customers ... 24/7. , iFitDress.com is a distinguished dress manufacturer, and it ... by worldwide customers for a very long time. The CEO ... a customer will be able to buy not only a ...
Breaking Medicine News(10 mins):Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 2Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 3Health News:ReAdmission Solutions, LLC Selects Essette 2Health News:Trendy Long Black Evening Gowns Now Provided By iFitDress.com 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 3Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2
... release is available in Spanish . , Ann ... with the supply of hospice care available in a county, ... Pain and Symptom Management this month. Local availability ... are end-of-life services that have been shown to improve pain ...
... AURORA, Colo. (May 8, 2011) Liposuction has become one ... been around since 1974 and there are now more than 450,000 ... recent study by Teri L. Hernandez, PhD, RN and Robert H. ... have found that the fat eventually returns within one year, ...
... -- Night owls who consistently stay up late may be ... study finds. Researchers at Northwestern University in Chicago found ... calories in the evening and eat more fast food than ... study, published online in the journal Obesity , examined ...
... Research Council lays out a framework for the U.S. ... the public health consequences of its decisions concerning a ... provides a common internal language to discuss potential options ... the relevant health dimensions for FDA decision making. ...
... At the 18th Annual Conference of the ... in conjunction with the 11th International Conference on Neuronal ... 2011 in Clearwater Beach, Florida, the ASNTR awarded The ... Donald Eugene Redmond, MD, professor of neurosurgery, Yale University ...
... DETROIT Nurse-driven, open-access colonoscopy programs are as ... with a gastroenterologist, according to researchers at Henry ... significant differences in safety outcomes related to perforation ... bleed, or death," says Gregory Olds, M.D., chief ...
Cached Medicine News:Health News:Supply of hospice services strongly associated with local area's median household income 2Health News:Do you think liposuction will get rid of that fat forever? 2Health News:Burning the Midnight Oil May Lead to Weight Gain 2Health News:FDA could analyze public health consequences of its decisions better 2Health News:Yale and Rush University scientists receive Sanberg Awards from ASNTR 2Health News:Yale and Rush University scientists receive Sanberg Awards from ASNTR 3Health News:Henry Ford Hospital study: Open-access colonoscopy is safe 2
... Embla microplate washers available to ... most cell-based assays. Embla 384 ... that have been optimized to ... are robotic compatible and have ...
... The Labcyte miniGene LW is a new plate ... to 96 and 384 channel microplates with flat, ... equipped with 8 or 16 channel nozzle heads. ... a breeze. An optional plate stacker is available ...
Space-saving counter top model,User initiated manual defrost,Standard features (see above),Internal freezing compartment,Removable half-shelf in refrigerator,Two shelves in door,UL 471 Commercial Ref...
... Produce Up to 8000 L/day of ... systems are designed to produce up to ... from potable tap feedwater., One Complete Purification ... integrated into a centralized system, providing total ...
Medicine Products: