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MedAvante Launches Service to Boost Reliability of Assessments to Reduce Risk of Failed Alzheimer's Disease Trials
Date:6/2/2010

mer's Disease, which could triple by 2050, but translating those gains into treatments will require well-executed clinical trials."

Such an approach can impact the overall outcomes of studies. By reducing inter-rater variability, results are more consistent, making it easier to identify whether a drug is having an effect.

"When experimental therapies for Alzheimer's Disease fail in clinical trials, or there are mixed or inconclusive results, one of the questions that naturally comes up is whether the intervention simply doesn't work or whether the methodology used for assessing patients could have been flawed," said Pierre Tariot,  Director, Memory Disorders Center Banner Alzheimer's Institute, Research Professor of Psychiatry, University of Arizona College of Medicine and MedAvante Alzheimer's Advisory Board co-chair, "It is a potentially critical issue in making go-no go decisions in the development process, and of particular concern in the Alzheimer's field, since the need for new, effective treatments is so acute and the development process so fraught with peril."

The CQC process, developed in collaboration with an advisory board of leading academics, includes several components designed to maintain the highest quality of those evaluations over the years of an Alzheimer's Disease trial. First, the participating raters are extensively trained to administer with the same standardized approach the key rating scales used in Alzheimer's studies, including the ADAS-Cog, ADCS-ADL, MMSE, CDR, and ADCS-CGIC.  Second, after the training they are then evaluated and qualified as ready to begin the trial. During the trial, each rater's assessments are continually monitored by a centralized cohort of expert trainers to ensure consistency and provide additional training if indicated. MedAvante's Monthly Clinical Trial D
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SOURCE MedAvante, Inc.
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