Navigation Links
Mechanism for Cardiac Effects of Trevena Angiotensin Receptor Biased Ligands Examined in Published Study
Date:7/30/2013

KING OF PRUSSIA, Pa., July 30, 2013 /PRNewswire/ -- Trevena, Inc., the leader in the discovery of G-protein coupled receptor (GPCR) biased ligands, announced today the publication of new findings related to the mechanism of action of its Angiotensin II Type 1 Receptor (AT1R) biased ligands. The publication describes work led by R. John Solaro PhD, Distinguished University Professor and Head of the Department of Physiology and Biophysics at the University of Illinois at Chicago, performed in collaboration with Trevena scientists.  The studies evaluated the molecular mechanisms of action for TRV120023, a molecule closely related to Trevena's clinical stage asset, TRV027, which is in Phase 2 testing for the treatment of acute heart failure. TRV027 is being developed by Trevena under a recently announced collaborative licensing option agreement with Forest Laboratories Inc. (NYSE: FRX).

The article, entitled "The Beta-arrestin-Biased Ligand TRV120023 Inhibits Angiotensin II-Induced Cardiac Hypertrophy While Preserving Enhanced Myofilament Response to Calcium", was published online, ahead of print, July 19, 2013, in the American Journal of Physiology - Heart and Circulatory Physiology.

Work in Dr. Solaro's laboratory showed that TRV120023 blocked cardiac hypertrophy in rats, while stimulating biochemical pathways linked to increased cardiac contractility.  TRV120023 increased the sensitivity of cardiac myofilaments to calcium, suggesting that TRV120023 and molecules like it, such as TRV027, can increase cardiac contractile force ("inotropy") through a mechanism distinct from classic inotropes, which are associated with cardiac arrhythmia and increased mortality. Dr Solaro said of the published work, "these experiments suggest that Trevena's biased ligands regulate the heart's contractile machinery through a novel mechanism which may simultaneously block cardiac dysfunction while promoting cardiac contractility"'/>"/>

SOURCE Trevena, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Lexicon Presents Data Regarding the Mechanism of Action and Safety of LX4211 at American Diabetes Association Meeting
2. Omeros Elucidates Mechanism of its PDE7 Inhibitors in Addiction
3. Stereotaxis Releases V-Sono™ Intracardiac Echocardiography Module for the Vdrive™ Remote Navigation System
4. Cardiac Dimensions® Announces Publication of TITAN Clinical Trial Data in European Journal of Heart Failure
5. eCardio Teams Up with Heart Rhythm Society for Month-Long Campaign to Raise Awareness of Cardiac Arrhythmias
6. Neal K. Long appointed as Chief Executive Officer at Cardiac Science
7. Cardiac Rhythm Management Devices Market to 2017 - Technological Innovations, Regulatory Approvals and Increasing Disease Prevalence Present Growth Opportunities
8. Cardiac Science to Supply Q-Tel Data to AACVPR Cardiac Rehabilitation Registry
9. Ablation Devices Market to 2016 - (Radiofrequency, Cryoablation, Microwave, Ultrasound, Hydrothermal, Radiation, Cardiac, Cancer and Gynecology) - Global Market Forecast and Trends Analysis by Technology, Devices & Applications
10. North America Cardiovascular Devices Market Outlook to 2018 - Cardiac Rhythm Management, Interventional Cardiology, Peripheral Vascular Devices, Electrophysiology Prosthetic Heart Valves and Others
11. Brazil Cardiovascular Devices Market Outlook to 2018 - Cardiac Rhythm Management, Interventional Cardiology, Peripheral Vascular Devices, Electrophysiology, Prosthetic Heart Valves and Others
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 10, 2014 CVS Caremark Corporation (NYSE: ... approved a quarterly dividend of $0.275 (27.5 cents) per share ... August 1, 2014, to holders of record on July 21, ... Caremark is dedicated to helping people on their path to ... the United States . Through the company,s more ...
(Date:1/15/2014)... Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the addition of ... Size, Share, Growth, Trends And Forecast, 2013 - 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 ) Dental consumables ... to treat dental impairments, for tooth restoration and in ...
(Date:1/15/2014)... 15, 2014 Massachusetts General Hospital (MGH), the ... ) announced today that they have launched a ... therapeutic targets and develop novel therapies for inflammatory ... millions worldwide. The MGH-Broad-Amgen collaboration brings together scientists ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
(Date:7/11/2014)... FL (PRWEB) July 11, 2014 American ... on RFD-TV, next Tuesday, July 15, 2014, at 8:30 ... Sunbelt's line of proprietary products, which are designed and ... crops. Audiences will learn how these products help the ... environment in which it is grown. , The show ...
(Date:7/11/2014)... Alliance Labs announced that they will be featured ... Jr, airing later this year 2014, via Discovery Channel. ... Innovations will explore DocuSol® Kids, a mini-enema containing a ... base designed to give adolescents general constipation relief. Viewers ... hyperosmotic laxative by drawing water into the bowel from ...
(Date:7/11/2014)... July 11, 2014 College athletes experiencing ... week of injury, but developed recurrent instability in 63% ... American Orthopaedic Society for Sports Medicine’s ( AOSSM ) ... physicians in providing the most optimal treatment plans for ... an anterior shoulder instability event, and found that 33 ...
(Date:7/11/2014)... 11, 2014 Anterior Cruciate Ligament (ACL) ... the type of material used to create a new ... game, say researchers presenting their work today at the ... Medicine ( AOSSM ). , “Our study ... (tissue harvested from a donor) fail more frequently than ...
(Date:7/11/2014)... repaired knee Anterior Cruciate Ligament (ACL) happens all too ... the American Orthopaedic Society for Sports Medicine,s (AOSSM) Annual ... risk factors may minimize the chance of a future ... few risk factors such as, age, activity level and ... of re-injury," said lead author, Christopher C. Kaeding, MD ...
Breaking Medicine News(10 mins):Health News:New Episode of American Farmer Featuring Sunbelt, UniSouth Genetics, and Michigan Milk Producers Association Airing on RFD-TV 2Health News:Alliance Labs & DocuSol® to be Featured in Upcoming Episode of Innovations 2Health News:Intercollegiate Contact Athletes with Shoulder Instability Return to In-Season Sports, Study Shows 2Health News:ACL Reconstructions May Last Longer With Autografts 2
... antibodies in migrant birds in five Siberian regions, a spokesman ... ,"Out of over 4,000 samples taken in the area this ... genetic material of the A-H5 virus and antibodies in their ... the presence of antibodies meant that either the birds had ...
... assess the effectiveness and tolerability of subdermal implantable contraceptives ... that they were all good at preventing pregnancy. ... be any more or less effective than the others ... effect with all the implants was changes in bleeding ...
... atrial fibrillation (AF) have irregular heart beats and have a ... (atria) of their hearts. These clots can then travel to ... ,One way of reducing the risk of this occurring is ... clots. Two commonly used options are anticoagulants that inhibit the ...
... smoking to secure peoples' rights to the highest standards of ... implementing a comprehensive anti-tobacco law to reduce the spread of ... Ali bin Shukur, Under-secretary of the Ministry of Health, was ... bill on smoking is being deliberated at the UAE Ministerial ...
... found in turmeric may help beat Alzheimer's, which is ... ,Researchers isolated the compound 'bisdemethoxycurcumin' found in turmeric, which ... the body against infections and diseases. ... patients and treat the incurable and fatal brain condition, ...
... six-month phase of a calorie-restriction study conducted at the ... Aging (USDA HNRCA) at Tufts University suggest that,accepting food ... important component of weight management. ,Supplemental results ... Restricting Intake of Energy (CALERIE) trial provide new insights ...
Cached Medicine News:Health News:Anticoagulants is Better for Atrial Fibrillation 2Health News:Food Cravings are Linked to Weight Managenemt 2Health News:Food Cravings are Linked to Weight Managenemt 3
... Addressing the key clinical and economic issues ... System is designed to maximize tension control ... The system combines efficient instrumentation with a ... Grip system is indicated for general orthopaedic ...
... In 1985, the worlds first ... by Howmedica Osteonics as a means ... wire for trochanteric reattachment procedures. Today, ... papers demonstrating clinical successes, the Dall-Miles™ ...
The Assistant Free Self-Retaining Hip Surgery Retractor System is used for hip arthroplasty and hip fracture surgery....
... have become the accepted standard for,excellence and ... AML Total Hip System was the first ... meet the needs for biological fixation in ... 15 years of documented clinical performance, the ...
Medicine Products: