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Mayo Clinic Study Shows Drug Could Effectively Treat, Prevent the Spread of Breast Cancer
Date:11/1/2007

riments in mouse models to determine whether 2ME2 would be an effective drug against breast cancer. The results are promising. Researchers described 2ME2 as an "attractive candidate for controlling tumor growth, metastasis to bone and bone disorders," such as osteolysis caused by the spread of breast cancer to bone. Based on the study findings, the researchers propose that 2ME2 be used as a therapeutic agent to target primary tumors, metastasis to bone and tumor-induced osteolysis.

There are few effective treatments for advanced breast cancer, but in this case, the study authors feel that 2ME2 has the potential to improve the prognosis of patients with advanced breast cancer.

"Targeting metastatic tumors at sites of metastasis would be of great benefit for patients who have advanced cancer. Destroying tumors in bone and also slowing the development of osteolytic lesions would be desirable therapies and greatly improve the prognosis of patients who have bone metastasis," the authors state.

In summary, Mayo Clinic researchers found that 2ME2 could:

* effectively target breast cancer cells

* prevent the spread of breast cancer cells to bone

* protect bone from osteolysis, which is a type of bone metastasis in

which the bone is eaten away by cancer cells.

Although clinical trials of 2ME2 for breast cancer patients have not taken place, other clinical studies of 2ME2 have been conducted. These trials are based on an oral version of 2ME2 to treat primary tumors, but this method has its limitations, as the oral version of 2ME2 is poorly suited to getting into the blood system and reaching tumors. The new Mayo Clinic study resolves this by delivering 2ME2 by injection and in a lower dose -- eight times lower than the comparable oral version used in mouse models.

"We found a complete reduction of tumors in the soft tissue (mammary fat glands) and in tumors in the bone. It targeted and blocked the metastasis f
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SOURCE Mayo Clinic
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