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Mayo Clinic Studies Find REM Sleep Behavior Disorder is Associated with Other Features of Neurodegenerative Disorders
Date:4/15/2008

ire, a validated screening measure for RBD, researchers determined that 8 percent of these individuals had probable RBD. Twenty-one percent with probable RBD had anxiety and 11.5 percent had apathy (compared with 8 percent and 4 percent, respectively, for individuals without RBD). Those individuals with RBD had significantly lower scores on neuropsychological measures of attention and executive functioning, such as concentration, decision making, and higher-order problem solving. Additionally, researchers found that 1.8 percent of the individuals had both RBD and parkinsonism.

"There is currently no treatment to delay the onset or prevent dementia or parkinsonism in patients with RBD who are destined to develop these neurologic problems in the future," says Dr. Boeve. "Our ultimate goal is to use therapies that would delay the onset or prevent these problems from ever developing in patients who have a form of RBD that reflects an evolving neurodegenerative disease. However, much more research is needed to get to that point."

Dr. Boeve and his team will continue to study this group of patients to better understand how RBD is associated with neurodegenerative disease. Other members of the Mayo Clinic research team included Jennifer Molano, M.D., Ebru Mihci, M.D., Rosebud Roberts, M.B.Ch.B., Yonas Geda, M.D., David Knopman, M.D., Eric Tangalos, M.D., Glenn Smith, Ph.D., Robert Ivnik, Ph.D., Ruth Cha, V. Shane Pankratz, Ph.D., Michael Silber, M.B.Ch.B., Tanis Ferman, Ph.D., and Ronald Petersen, M.D., Ph.D.

To obtain the latest news releases from Mayo Clinic, go to http://www.mayoclinic.org/news. MayoClinic.com (http://www.mayoclinic.com) is available as a resource for your health stories.


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