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Mayo Clinic Proceedings January Tip Sheet
Date:1/18/2008

rial assessing the effect of selenium in lowering the risk of prostate cancer is currently underway.

The bottom line according to Aditya Bardia, M.D., lead author of the study, is that antioxidants do not lower the risk of cancer and beta carotene might actually increase cancer risk among smokers. Selenium might have beneficial properties, but it cannot be recommended for general use until more evidence is available.

In addition to Drs. Montori and Bardia, authors of the article include James Cerhan, M.D., Ph.D.; Amit Sood, M.D.; Paul Limburg, M.D.; and Patricia Erwin, all of Mayo Clinic; and Imad Tleyjeh, M.D., King Fahd Medical City, Riyadh, Saudi Arabia.

Researchers Issue Practical Guidelines for Workplace Drug Screening

Commonly used in health care, workplace and criminal settings, drug testing has become widespread during the past decade. Urine drug screens have been the most common method for analysis because of ease of sampling. But this form of testing does not always yield accurate results, and serious medical or social consequences can occur when results are not confirmed by additional testing. In the January issue of Mayo Clinic Proceedings, researchers provide up-to-date information about proper evaluation of urine drug screens. The authors also examine the potential problems associated with testing for several commonly abused drugs (including alcohol, amphetamines, benzodiazepines, opioids, marijuana, cocaine, phencyclidine (PCP), and tricyclic antidepressants) and they discuss how to evaluate urine drug screens for adulterations, substitutions and potential false-positive results.

Authors of this article are Karen Moeller, PharmD., Pharmacy School, University of Kansas Medical Center, Kansas City; Kelly Lee, PharmD., Department of Clinical Pharmacy, UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, Calif.; and Julie Kissack, PharmD., Department of Pharmacy Practice, Mercer University, Col
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