Navigation Links
Mayo Clinic Finds Capsule Endoscopy Can Detect Intestinal Damage Caused by Celiac Disease
Date:2/27/2008

Study shows extent of intestinal damage does not explain patients' symptoms

ROCHESTER, Minn., Feb. 27 /PRNewswire-USNewswire/ -- Mayo Clinic researchers have found that capsule endoscopy can provide a magnified view of the intestinal damage caused by celiac disease. This new information can help physicians detect and diagnose celiac disease, as well as measure intestinal healing following treatment. These findings are published in this month's issue of Clinical Gastroenterology and Hepatology.

Approximately 3 million Americans, or about one in 100 people, are affected by celiac disease. Individuals who have celiac disease are intolerant to proteins (collectively called gluten) found in wheat, barley and rye grains. In these people, gluten stimulates an immune reaction in the small intestine, which causes intestinal damage and the subsequent inability to absorb certain nutrients from food. Treatment is to avoid foods containing gluten (the so-called gluten-free diet). Untreated, celiac disease can cause many medical complications and increase the risk of death. However, when a medically supervised diet plan is implemented, patients can experience almost complete reversal of symptoms and complications from the disease.

"Capsule endoscopy allows us to look at the entire 30 feet of the small intestine, not just the first one to two feet that can be visualized with other types of endoscopy," says Joseph Murray, M.D., the study's lead author and a gastroenterologist at Mayo Clinic.

The capsule is approximately the size of a large vitamin, and it includes a miniature color video camera, light, battery and transmitter. The patient swallows the capsule, which takes approximately eight hours to move through the small intestine. As the capsule moves through the digestive tract, images recorded by the video camera are transmitted to a number of sensors attached to the patient's torso and recorded digitally on a device worn around the patient's waist. Then, the recording device is removed and its contents are downloaded to a computer for examination.

This study, the first of its kind, used capsule endoscopy to view intestinal damage in 37 patients with untreated, biopsy-proven celiac disease. Ninety-two percent had visible damage detected by capsule endoscopy. Twenty-two patients had extensive damage in the duodenum (first portion of the small intestine) and patchy damage throughout the jejunum (the small intestine's middle portion). Twelve patients had damage limited to the duodenum, and one patient had only patchy damage throughout the jejunum. However, no association was shown between the extent of intestinal damage and the patients' symptoms. Six months after a gluten-free diet was implemented, capsule endoscopy showed improvement, or decreased intestinal damage, in most patients.

"This study confirmed our suspicions that the most extensive intestinal damage in celiac disease patients is primarily to the duodenum. However, we were surprised to discover no correlation between extent of intestine damage and patient symptoms," says Dr. Murray. "Capsule endoscopy will now be another tool to diagnose celiac disease and detect intestinal damage both prior to and following treatment."

Other members of the Mayo Clinic research team included Alberto Rubio Tapia, M.D., Carol Van Dyke, Deanna Brogan, Mary Knipschield, Brian Lahr, Ashwin Rumalla, Alan Zinsmeister, Ph.D., and Christopher Gostout, M.D.

Each year, physicians at Mayo Clinic's campuses in Arizona, Florida and Minnesota treat hundreds of patients who have celiac disease. For more information on celiac disease treatment at Mayo Clinic, visit http://www.mayoclinic.org/celiac-disease/.

To obtain the latest news releases from Mayo Clinic, go to http://www.mayoclinic.org/news. MayoClinic.com (http://www.mayoclinic.com) is available as a resource for your health stories.


'/>"/>
SOURCE Mayo Clinic
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Michael J. Fox Foundation Commits Up to $3 Million for Clinical Trials That Can Improve Treatment of Parkinsons Disease
2. Treatment of First Patient in Phase I Clinical Trial of Bionomics Anti-Cancer Drug BNC105
3. Alegent Health Sees Positive Results From Recent Clinician Usability Study Collaboration With Siemens and Motion Computing
4. Associated Foot & Ankle Specialists Enrolling Patients With Chronic Diabetic Foot Ulcers for MATRIX Clinical Trial
5. Dong-A PharmTech Co., Ltd. Announces Portal Hypertension Clinical Trial With Udenafil
6. Arbios Receives Conditional Approval from the FDA to Initiate Pivotal Clinical Trial for SEPET(TM)
7. ATS Medical Announces Initial Clinical Results of Stand-Alone Atrial Fibrillation Procedures Using ATS CryoMaze Product Line
8. ISTA Pharmaceuticals Announces Physician-Sponsored Clinical Study of Xibrom(TM) Combination Therapy with Lucentis(R)
9. Accumetrics Announces $28.8 Million Financing and Initiation of Pivotal Clinical Trial
10. Pre-Clinical Data Show Intracellular Pathways Affected by ONCONASE(R)
11. Oxygen Relieves IBS and Constipation Symptoms in New Clinical Studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... , May 24, 2016 Open ... in Clinical Neurophysiology  Elsevier , a ... and services, today announced the launch of ... access journal that focuses on clinical practice issues in ... reports, clinical series, normal values and didactic reviews. It ...
(Date:5/23/2016)... PUNE, India , May 23, 2016 /PRNewswire/ ... research report "Patient Handling Equipment Market by Product ... Type of Care (Bariatric Care, Critical Care, Wound), ... Hospital) - Forecast to 2021", published by MarketsandMarkets, ... reach USD 17.18 Billion by 2021 at a ...
(Date:5/23/2016)... ALBANY, New York , May 23, 2016 /PRNewswire/ ... new market report titled, " Exocrine Pancreatic Insufficiency Market ... Forecast 2013 - 2023 ." According to the report, ... at a CAGR of 8.3% from 2015 to 2023 ... pancreatic insufficiency (EPI) is a condition characterized by the ...
Breaking Medicine Technology:
(Date:5/24/2016)... ... May 24, 2016 , ... American Gene Technologies ... to its board of directors. Otterstatter is co-founder, president and CEO of ... technological innovations that lead to broad-based healthcare solutions. , “Jon knows how to ...
(Date:5/24/2016)... ... 24, 2016 , ... WaterAid launched the #perioddrama campaign to mark Menstrual Hygiene Day ... women around the world who do not have access to a toilet, even when they’re ... their dread of #perioddrama. The (sometimes hilarious) results help shine a light on the awkwardness ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... patient Services To Begin In June , Aloria Health, specializing in a re-imagined, ... opening of Aloria Milwaukee, its first treatment facility for outpatient, day treatment and ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... and tick-borne disease research and education, today announced that it has named Scott ... of the Bonnie J. Addario Lung Cancer Foundation (ALCF) in San Francisco, where ...
(Date:5/24/2016)... ... 24, 2016 , ... Dignity Health has announced it will be opening a ... licensed under Dignity Health Arizona General Hospital, which opened last year in the West ... that the new facility will complement Dignity Health’s existing hospitals’ emergency departments. “We ...
Breaking Medicine News(10 mins):