Navigation Links
MatTek's EpiDerm In Vitro Tissues Headed for Validation in Europe
Date:10/8/2008

Acceptance Will Reduce Animal Use in Cosmetics and Chemicals Testing

ASHLAND, Mass., Oct. 8 /PRNewswire/ -- MatTek Corp. today announced that results of a recently completed US and European multi-laboratory "catch-up" validation study on MatTek's EpiDerm in vitro human skin tissue equivalent. The test results demonstrated the required sensitivity and specificity for EpiDerm to be accepted as a validated alternative to animal testing for determining human skin irritation by the European ECVAM Scientific Advisory Committee (ESAC).

Horst Spielmann, former Director, ZEBET (BfR), commenting on the skin irritation catch-up validation studies in AltTox.org, noted that the "take home message" from these new studies is that EpiDerm was not only successfully validated using just one endpoint (cytotoxicity -- MTT viability), but also that the EpiDerm classification test results met the criteria set by the validated skin irritation test method.

The results obtained for EpiDerm in the catch-up validation studies have been submitted to ECVAM for approval by the ECVAM Scientific Advisory Committee (ESAC) at its next meeting on Nov. 3-4, 2008.

Spielmann went on the say that it would be helpful in promoting the new in vitro skin irritation test in Europe if these catch-up validation results are taken into account at the OECD Expert Meeting being held in Berlin, Germany on October 20-21, 2008 to review the new Draft OECD Test Guideline on "In Vitro Skin Irritation: Human Skin Model." Inclusion of EpiDerm in this OECD Test Guideline will lead to EpiDerm acceptance in the very near future to meet the skin irritation testing requirements of the 6th amendment of the EU Cosmetics Directive and of the new EU Chemicals Directive (REACH).

John Sheasgreen, MatTek's President, added, "It is very gratifying to see MatTek's almost 15 years of in vitro human tissue equivalent development and production culminating in the full validation of these tissues as alternatives to animal testing."

About MatTek -- MatTek Corp., founded in 1985, is the world's largest independent producer of in vitro human epithelial tissue equivalents. With over 400 technical references supporting its of claim of "Unsurpassed Tissue Reproducibility," MatTek human tissue equivalents are used in product development, claims substantiation (over 100 company patents cite the use of MatTek tissues), safety assessment, and drug discovery/development in many industries including Cosmetics, Personal Care, Household Products, Chemicals, Pharmaceuticals and Biotech.


'/>"/>
SOURCE MatTek Corp.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria
2. Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models
3. Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficile Bacteria
4. Georgia Reproductive Specialists Participates in Largest-Ever In Vitro Fertilization Clinical Trial in the World
5. Newly Published Study Shows OPKOs siRNA Bevasiranib Is Taken Up by Target Tissues in the Eye
6. NewCardio Announces Positive Results From Third Clinical Validation Study
7. M. D. Anderson to Initiate Clinical Validation Study on Rosetta Genomics MicroRNA-based Diagnostic Assay Identifying the Origin of Cancer Metastases
8. Michael J. Fox Foundation Awards $2.4 Million for Validation of Nine Promising Therapeutic Targets for Parkinsons Disease
9. ACRIN Study Endorses Virtual Colonoscopy - Validation for Colon CAD Software Maker Medicsight plc
10. NVA237 Phase II Results Presented at the European Respiratory Society Annual Meeting Show Promising Efficacy and Tolerability With Potentially Faster Onset Than Tiotropium
11. IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following September Meeting of European Committee for Medicinal Products for Human Use (CHMP)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, ... 8th Day Software and Consulting, LLC , and named ... 8th Day Software, based in Tennessee , ... 8th Day expands EnvoyHealth,s service offerings for health care ... "In an interoperable ...
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... property taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, ... many overseas retirement havens have extremely low property-tax rates, which contributes to the ...
Breaking Medicine News(10 mins):