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Mast Therapeutics Announces Positive Data In Model Of Heart Failure
Date:1/6/2014

SAN DIEGO, Jan. 6, 2014 /PRNewswire/ -- Mast Therapeutics, Inc. (NYSE MKT: MSTX) today announced that, in a placebo-controlled, nonclinical model of chronic heart failure, MST-188 demonstrated a statistically significant improvement in numerous parameters of heart function, including left ventricular ejection fraction and end-systolic volume, stroke volume and cardiac output.  Notably, a single two-hour infusion of MST-188 resulted in improvements that were significant immediately (at the end of MST-188 administration) and remained significant at one week (and, in some cases, at two weeks) after MST-188 administration. 

Hani N. Sabbah, Ph.D., Professor of Medicine & Director of Cardiovascular Research at Henry Ford Health System, said: "These data clearly show that MST-188 improves left ventricular ejection fraction and end-systolic volume, both of which are important indicators of long-term mortality and morbidity in chronic heart failure, with some effects lasting up to 2 weeks post-infusion.  The durability of response is very encouraging and merits clinical investigation."

Santosh Vetticaden, M.D., Ph.D., Chief Medical Officer of Mast Therapeutics, said: "Heart failure is an area of significant unmet medical need that accounts for over 1 million hospitalizations every year in the U.S. alone.  Although there have been modest improvements in treatment, heart failure remains associated with significant mortality and high rates of hospital admission and readmission.  We look forward to discussing these results with heart failure experts and potential partners and mapping our clinical development strategy in this exciting new indication." 

The Company has submitted data from this study for presentation at an upcoming medical conference and will provide an update on its plans for MST-188 in heart failure later in 2014. 

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SOURCE Mast Therapeutics, Inc.
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