Navigation Links
Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's
Date:7/29/2008

e radioactivity of the first amyloid-imaging tracer, called 11C-PIB or Pittsburgh Compound B, is relatively short-lived. With this agent, based on radioactive carbon, half of the radioactivity is lost every 20 minutes. This means that it must be manufactured onsite, a process that requires a cyclotron (a type of particle accelerator), which is rarely found in community hospitals. This limitation has prompted a search for longer-lived tracers, such as 18F-labeled agents, based on radioactive fluorine, which would be suitable for regional production and wider community use.

In the study, three 18F-labeled compounds were evaluated in 42 cognitively healthy elderly volunteers and 39 individuals with Alzheimer's. Each participant received a single intravenous injection of one of the compounds followed by PET imaging.

People with Alzheimer's showed retention of all three tracers in brain areas expected to be high in amyloid. In contrast, cognitively healthy volunteers showed rapid removal of the tracers, with minimal retention in the brain. Two individuals diagnosed with Alzheimer's had a pattern of tracer uptake similar to healthy volunteers. Chart notes for both suggested unusual presentations - prominent Parkinsonism in one case and slowly progressive dementia in the other.

While the three compounds were similar in pattern and amount of tracer retention, they differed in how they were processed by the body in ways that favored one compound, 18F-AV-45. For example, 18F-AV-45 showed rapid uptake and steady levels were maintained in the brain between 50 and 90 minutes post injection. This allowed high quality images to be obtained from PET imaging beginning 50 minutes after 18F-AV-45 administration, with minimal inconvenience or delay for the patient or the imaging center, according to the researchers.

"18F-AV-45 is being used as a research tool today, but it has the potential to aid in the diagnosis and early detection of Alzheimer's in a comm
'/>"/>

SOURCE Alzheimer's Association
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. AviaraDx Confirms That Combination of Two Molecular Biomarkers Improves Prediction of Disease Recurrence in Early Stage Breast Cancer Patients
2. Biomarkers May Reduce the Need for Biopsies and Offer Personalized Care for Heart and Lung Transplant Patients
3. Vermillions Biomarkers Prove Beneficial in Identifying Women With Ovarian Cancer and Detecting Early-Stage Disease
4. QIAGEN and Center for Molecular Medicine Create Research Collaboration for Molecular Diagnostic Markers for Breast Cancer, Other Womens Health Issues
5. Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
6. JDRF and Lilly Partner to Fund Research to Identify Beta Cell Biomarkers
7. CV Therapeutics Anti-Ischemic Agent Ranexa(R) Significantly Reduces HbA1c and Other Markers of Diabetes in MERLIN TIMI-36
8. NicOx Completes Enrollment of Two Ambulatory Blood Pressure Measurement (ABPM) Studies for Naproxcinod in Hypertensive OA Patients
9. Study Shows Use of AdvanDxs PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections
10. Fish Oil and Red Yeast Rice Studied for Lowering Blood Cholesterol
11. Hibernation-On-Demand Drug Hydrogen Sulfide Significantly Improves Survival After Extreme Blood Loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... , July 28, 2014  VigeneTech, Inc, ... release of LEGENDplex™ Data Analysis Software, an OEM ... flow cytometers.  BioLegend develops and offers varieties of ... cytometers. With the support of VigeneTech,s data analysis ... accurately analyzed and easily reported ...
(Date:7/28/2014)... , July 28, 2014  A prospective ... Sweden has validated the performance ... platforms and has associated volumetrically assessed breast density ... Cancer Epidemiology, Biomarkers & Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), ... a tool for widespread breast cancer risk assessment," ...
(Date:7/28/2014)... , July 28, 2014  ALPHAEON ... lifestyle healthcare and subsidiary of Strathspey ... acquired Physician Recommended Nutriceuticals (PRN) ® , a ... related products for dry eye and ... a transaction worth up to $55M. ...
Breaking Medicine Technology:VigeneTech Releases New Powerful Software for Flow Cytometry Data Analysis 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4ALPHAEON Acquires PRN, A Leading Specialty Nutriceutical Company 2ALPHAEON Acquires PRN, A Leading Specialty Nutriceutical Company 3
... DIEGO, Nov. 19 Accumetrics, Inc., developer of the ... reactivity, announces that its market-leading VerifyNow P2Y12 Test was ... which was presented during a Late Breaking Clinical Trials ... The VerifyNow P2Y12 Test is used to measure the ...
... , , HOPKINTON, Mass., Nov. 19 ... a leading provider of tools and services for drug ... partnership between the company,s contract research organization, Caliper Discovery ... to provide customized outsourced medicinal chemistry and in vitro ...
Cached Medicine Technology:VerifyNow(R) System Highlighted in POPular Study Comparing Platelet Reactivity Tests 2Caliper Life Sciences Partners with Prestwick Chemical to Offer Customized Chemistry and Biology Programs for Drug Discovery Research 2Caliper Life Sciences Partners with Prestwick Chemical to Offer Customized Chemistry and Biology Programs for Drug Discovery Research 3
(Date:7/29/2014)... 2014 Riverdale Urgent Care is making ... Through their presence at local events, partnerships and other ... than just a medical service for the Riverdale neighborhood. ... in support of Riverdale RiverFest and South Riverdale Street ... features local musicians and entertainers, arts and crafts, boat ...
(Date:7/29/2014)... July 29, 2014 Gout was one called ... have proven that last statement essentially moot since many ... people still do not have are the resources to deal ... it costly to maintain treatment for it, but the effects ... activities to a grinding halt. , Alternative medicine ...
(Date:7/29/2014)... July 29, 2014 PeopleKeys today announced ... to teach students how to train and certify others ... Certified Behavioral Consultant Trainer , will be taught by ... of Training John Schindell as a live Tele-course over ... , The Certified Behavioral Consultant Trainer course will use ...
(Date:7/29/2014)... Tucson, Arizona (PRWEB) July 29, 2014 ... addition to an employer’s benefits package, or health and ... healthy work-life balance while providing an effective way for ... to take advantage of the program, employees specify the ... Vacation Savings Account. , An employer benefits from offering ...
(Date:7/29/2014)... July 29, 2014 The Multiple System ... has announced the appointment of five new members to ... Coalition announced the election of its executive directors. ... Board members and 2 Physician Advisors. These 12 ... Coalition mission of education, support, advocacy and research funding ...
Breaking Medicine News(10 mins):Health News:Riverdale Urgent Care of the Bronx, NY Puts a Face Back on Medicine 2Health News:Riverdale Urgent Care of the Bronx, NY Puts a Face Back on Medicine 3Health News:Gout Natural Remedy Report Review | The Ultimate Secret to Eliminating Gout Naturally – Vinamy.com 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 3Health News:Outski launches 401(play)™ Plan to Employers as Part of an Employee Benefit / Health and Wellness Program 2Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 2Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 3Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 4
... PAUL, Minn Call it a stroke of bad luck ... brought very good news for middle aged women. Women are ... to be due to expanding waist lines and heart disease. ... over the age of 18 who participated in the National Health ...
... disasters have been in the spotlight especially after recent ... specialists, well planned crisis management strategies are need of ... undergoing regular dialysis are not in dire straits due ... ,The July Clinical Journal of the ...
... icebergs have a major impact on the ecology of ... life, according to a new study by American researchers. ... they release far out at sea as they melt. ... nutrients, chlorophyll and krill out to a radius of ...
... who suffer bouts of nausea and vomiting during their pregnancies ... but it seems that going through morning sickness is a ... who have conducted a new study and found that women ... risk of developing breast cancer later in life than expecting ...
... hit out at media reports claiming that the she admitted to ... written on her Myspace blog was made up and not written ... blog. Someone made it up, Contactmusic quoted Allen, as saying. ... in a Canada TV show was misinterpreted by someone and was ...
... Wockhardt Hospital, Bangalore, have removed a large cancerous tumour from ... a statement that Prabhu Ram was diagnosed to be ailing ... led to difficulty in breathing, high fever and swelling of ... tumour arising from both the upper chambers of the heart, ...
Cached Medicine News:Health News:Stroke - Unfair to the Middle-aged Fair Sex 2Health News:Nephrologists Reassess Disaster Response Strategies 2Health News:Nephrologists Reassess Disaster Response Strategies 3Health News:Morning Sickness may Signify Lower Breast Cancer Risk 2Health News:Morning Sickness may Signify Lower Breast Cancer Risk 3
Halogen-free immersion oil based on ester oil....
Immersion oil composed on polyester polyol, diphenyl cresyl phosphate and tricyclodecane dimethanol....
Immersion oils may crystallize on storage. Can be redissolved on heating to 50ºC (1-2 hours)...
... The CoaguChek XS system is a compact, ... patients to experience a significant improvement in ... management of their condition. , , The ... to the proven CoaguChek S system. It ...
Medicine Products: