Navigation Links
Marinus Pharmaceuticals Issued Patent for Ganaxolone
Date:4/7/2011

NEW HAVEN, Conn., April 7, 2011 /PRNewswire/ -- Marinus Pharmaceuticals, Inc., the leader in development of neurosteroids for central nervous system disorders, today announced that the United States Patent and Trademark Office (USPTO) issued the company Patent Number 7,858,609 entitled, "Solid ganaxolone formulations and methods for the making and use thereof." The patent describes a novel class of small molecules to improve stability and bioavailability of nanoparticulate formulations of ganaxolone and will provide coverage until the end of 2026.

“Neurosteroids like ganaxolone have been difficult to formulate in the past because of differences in exposure that are dependent on the dose and amount of food in the stomach,” commented Kenneth Shaw, Ph.D., Senior Vice President, R&D at Marinus. “Marinus’ discovery of a novel class of stabilizing agents has produced new nanoparticulate formulations of ganaxolone that appear to be superior to historical formulations in minimizing these differences.”

The company has submitted a second patent application covering a new synthesis method for ganaxolone that decreases the number of process steps thus increasing cost efficiency.

About Ganaxolone

Ganaxolone is a synthetic neurosteroid and a derivative of the naturally occurring neuromodulator, allopregnanolone.  Ganaxolone has been administered to more than 950 healthy adult volunteers and patients in Phase 1 and Phase 2 studies. Completed Phase II epilepsy studies have generated data supportive of the efficacy and safety of ganaxolone in the treatment of both children and adults suffering from refractory epilepsy (patients who continue to have seizures despite taking multiple anticonvulsant drugs). Scientific research has suggested that ganaxolone therapy may be useful in the treatment of several other central nervous system disorders including posttraumatic stress disorder (PTSD) and Fragile-X syndrome (FXS). Ganaxolone is being developed as a first in class treatment in epilepsy, PTSD and FXS.

Marinus has successfully developed several proprietary and novel patented formulations of ganaxolone.

About Marinus Pharmaceuticals

Marinus is a specialty pharmaceutical company dedicated to the reformulation, development, and commercialization of novel drugs to treat serious neurological and psychiatric disorders. Marinus is located in Branford, Connecticut. Its investors include Domain Associates, Canaan Partners, Sofinnova Ventures and Foundation Medical Partners. For additional information, please visit the company’s Web site at www.marinuspharma.com.


'/>"/>
SOURCE Marinus Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Cempra Pharmaceuticals to Present at Two Upcoming Cambridge Healthtech Institute (CHI) Conferences
2. Reportlinker Adds Global: Pharmaceuticals Industry Guide
3. Optimer Pharmaceuticals and Cubist Pharmaceuticals Announce Collaboration to Co-Promote DIFICID™ (Fidaxomicin) for Clostridium difficile Infection in the United States
4. Valeant Pharmaceuticals Files Preliminary Consent Solicitation Statement With the SEC
5. Vista Partners Updates Coverage on Pro-Pharmaceuticals, Inc.; Raises Target Price to $3.22
6. Avanir Pharmaceuticals to Present at BioCentury Future Leaders in the Biotech Industry Conference
7. Trading Halted Today in Optimer Pharmaceuticals Stock
8. Cumberland Pharmaceuticals Appoints Rick S. Greene as Vice President, Finance & Accounting
9. Questcor Pharmaceuticals Announces Preliminary Operating Metrics for First Quarter 2011
10. Cardioxyl Pharmaceuticals Presents Data On Its Clinical Candidate, CXL-1020, at the 60th Annual American College of Cardiology Scientific Session
11. Dipexium Pharmaceuticals Updates Locilex™ Development Activities and Announces 2011 Milestones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)...  This report by Persistence Market Research examines ... the period 2016–2024. The primary objective of the ... to market opportunities in the global peripherally inserted ... the various dynamics that are expected to influence ... global peripherally inserted central catheters market over the ...
(Date:1/16/2017)... 16, 2017 Derek H. Potts , ... was recently appointed Liaison Counsel in California,s ... Xarelto cases. In this role, Potts was assigned to ... actively assist the Court and Co Lead Plaintiff,s Counsel. ... Adelman Jackson Fairchild & Wade and Ruth ...
(Date:1/16/2017)... ROCKVILLE, Md. , Jan. 16, 2017 /PRNewswire/ ... tomography (CT) systems market is valued at $4.9 ... applications for CT, coupled with an aging population ... incidence of chronic disease, is propelling the market ... report, Computed Tomography Markets , focuses on ...
Breaking Medicine Technology:
(Date:1/16/2017)... ... January 16, 2017 , ... ... Dental Center, is currently offering complimentary consultations and financing for orthodontics for a ... for bite irregularities and learn about their orthodontic options. Walk-in, late-evening, Saturday, and ...
(Date:1/16/2017)... ... 2017 , ... Permobil has just completed the acquisition of ... systems has a well-earned reputation for premium quality, with a focus on fit ... in the custom seating business, which enjoys strong demand, and it complements Permobil’s ...
(Date:1/16/2017)... ... 16, 2017 , ... Atlanta-based incentive company Incentive Solutions ... wheelchair accessibility industry, BraunAbility . Incentive Solutions will provide BraunAbility a debit ... With this new incentive plan, BraunAbility plans to continue their tradition of excelling ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... editor, attorney, science teacher, http://www.ageofautism.com/legal , Sharon Kleyne, America’s leading water ... Heckenlively to her nationally syndicated radio program, The Sharon Kleyne Hour Power of ...
(Date:1/16/2017)... ... 2017 , ... In 1985, the International Association of Eating ... an international multidisciplinary group of healthcare treatment providers and helping professions who treat ... mission at the grassroots level, iaedp launched MemberSHARE, an online peer community solely ...
Breaking Medicine News(10 mins):