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Marcadia and Lilly Sign Development, License Agreement for Novel Glucagon Program in Severe Hypoglycemia
Date:6/28/2010

INDIANAPOLIS, June 28 /PRNewswire-FirstCall/ -- Marcadia Biotech, Inc. and Eli Lilly and Company (NYSE: LLY) today announced that the companies have signed a development and exclusive license agreement for Marcadia's short-acting glucagon program, covering glucagon analogs that may provide greater convenience and ease-of-use than the current recombinant glucagon for the treatment of severe hypoglycemia. The program includes MAR531, a glucagon analog that is in preclinical development at Marcadia, as well as related backup compounds.

Under the terms of the agreement, Marcadia will continue to oversee development of the compound through regulatory approval in the U.S., while Lilly will be responsible for obtaining regulatory approval in countries outside the U.S. and for commercialization worldwide.  Financial terms of the collaboration were not disclosed.

"Glucagon is an important therapeutic for people with diabetes to treat an episode of severe hypoglycemia, but the currently marketed products require  reconstitution from a lyophilized (powder) form before administering an injection," said Enrique Conterno, president of Lilly Diabetes. "A new glucagon therapy that can be stored in solution form at room temperature and supplied in a convenient injection device could be an important advance for patients."

Fritz French, chief executive officer of Marcadia, added, "Lilly's long experience and expertis
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SOURCE Eli Lilly and Company; Marcadia Biotech, Inc.
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