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Manufacturing of Vaccines - Cell Culture Technology Gradually Replacing Egg-Based Manufacturing
Date:9/6/2011

accines 19

5.1.3 Pandemic Influenza Vaccines 19

5.2 Raw Materials 20

5.2.1 Process Design 20

5.2.2 Key Positions 20

5.2.3 Supporting Technology 21

5.3 Assembly 21

5.3.1 Inactivated Influenza Vaccine; Egg-Based Manufacture 21

5.3.2 Inactivated Influenza Vaccine; Cell Culture-Based Manufacture 23

5.3.3 Live Attenuated Influenza Vaccines; Egg-Based Manufacture 24

5.3.4 Live Attenuated Influenza Vaccines; Cell-Culture Based Manufacture 25

5.3.5 Parvovirus B19 VLP Vaccine 25

5.3.6 Process Design 26

5.3.7 Process Throughput 31

5.3.8 Key Positions 32

5.3.9 Supporting Technology 33

5.4 Inventory 35

5.4.1 Process Design 35

5.4.2 Process Throughput 37

5.4.3 Key Positions 37

5.5 Distribution 38

5.5.1 Process Design 38

5.6 Challenges Faced in Vaccine Manufacturing 38

5.6.1 Technological Expertise 38

5.6.2 Initial Capital Investment 39

5.6.3 Regulatory Challenges 39

5.7 Unmet Needs in Vaccine Manufacturing 40

5.7.1 High Yield Maintenance 40

5.7.2 Cost 41

5.7.3 Time 42

5.7.4 Regulation 44

6 Manufacturing of Vaccines - Vaccine Manufacturing Industry 45

6.1 Market Characterization of Vaccine Manufacturing Industry 45

6.1.1 Overview 45

6.1.2 Vaccine Production Capacity 46

6.1.3 Contract Vaccine Manufacturing Market 47

6.1.4 Demand vs Production 48

6.1.5 Drivers for Growth of Vaccine Manufacturing 48

6.1.6 Barriers for Growth of Vaccine Manufacturing 50

6.2 Competitive Assessment 51

6.2.1 Market Share 51

6.2.2 Profiles of Key Players 51

6.3 Emerging Technologies 57

6.3.1 Upstream Bioprocessing 57

6.3.2 Downstream Bioprocessing 57

6.4 Alliances for Vaccine Manufacturing 59

6.4.1 Vaccine Facility Construction Alliance 59

6.4.2 Contract Manufacturing Alliances 59<
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