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Major deCODE-led Study Underscores Role of the Brain in Obesity
Date:12/14/2008

REYKJAVIK, Iceland, December 14 /PRNewswire-FirstCall/ -- In one of the largest studies of its kind, a multinational team led by scientists from deCODE genetics (Nasdaq: DCGN) today report the discovery of common variations at seven new sites in the human genome found to influence obesity. The study analyzed more than 300,000 single-letter variations (SNPs) across the genome of more than 30,000 people from Iceland, the Netherlands, and the United States, and confirmed the findings in data from more than 40,000 individuals from Denmark and the US-based GIANT Consortium. deCODE is incorporating the novel SNPs on chromosomes 1, 2, 3, 6, 11, 12 and 19 reported today in its deCODEme(TM) personal genome analysis service, and subscribers will receive an update to their personal profiles. The paper, entitled "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity," is published today in the online edition of Nature Genetics at http://www.nature.com/ng, and will appear in an upcoming print edition of the journal.

"This study essentially doubles in one fell swoop the number of known and replicated genetic factors contributing to obesity as a public health problem. And what we are seeing in obesity are a large number of common genetic risk factors with a relatively modest impact on disease. One of the most notable aspects of these discoveries is that most of these new risk factors are near genes that regulate processes in the brain. This suggests that as we work to develop better means of combating obesity, including using these discoveries as the first step in developing new drugs, we need to focus on the regulation of appetite at least as much as on the metabolic factors of how the body uses and stores energy," said Kari Stefansson, CEO of
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SOURCE deCODE genetics Inc
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