Navigation Links
Major New Study Shows Aortic Valve Replacement Via Catheter Produces Better Outcomes Than Traditional Open-Heart Surgery

DETROIT, April 3, 2011 /PRNewswire/ -- A major new study presented today at the yearly scientific meeting of the American College of Cardiology (ACC) in New Orleans shows conclusively that replacing defective aortic valves in elderly patients through non-invasive "catheterization" – rather than through much more invasive open-heart surgery – leads to significantly better outcomes.

The new clinical trial study (PARTNER cohort A: Transcatheter valves noninferior to surgery), documents important scientific evidence for the fact that a new "transcatheter" approach to aortic heart valve replacement is safer and less strenuous for older patients than the older open-heart procedure.

The new high-tech method of implanting replacement aortic heart valves relies on delivering them to the heart via plastic catheters threaded through arteries, rather than implanting them after cutting through the chest.

The results of the large, authoritative study, presented at the ACC meeting – and conducted among 699 elderly patients at 26 sites in the U.S., Canada and Germany – confirmed that delivering new synthetic heart valves to elderly patients suffering from "aortic stenosis" (age-related valve-narrowing) via catheter tubes results in fewer deaths and about four times less severe bleeding than when the valves are delivered via traditional "chest-cracking" open-heart surgery.

The study is certain to have a major impact on interventional cardiac care, since it documents the importance of non-surgical approaches to heart valve replacement in elderly patients who are often too weak or impaired by disease conditions to endure the older form of chest surgery.          

"The findings that were presented today in New Orleans are very significant for older patients who need aortic valve replacement," said Theodore L. Schreiber, M.D., the president of the CVI and a catheterization pioneer who was the first cardiac physician in the world to design a method for delivering synthetic valves to the heart via the groin artery.  "The results of the randomized, multi-center trial show conclusively that implanting new aortic valves through catheter tubes is much easier on patients than subjecting them to the pain, trauma and infection-risk that accompanies open-heart surgery."

Only about a month ago, a multidisciplinary team of DMC physicians, nurses, research teams and technologists made headlines by achieving two aortic valve implants.  Using a new "Medtronic CoreValve" device expressly designed for that purpose, Dr. Schreiber and Dr. Ali Kafi, chief of clinical cardio-thoracic surgery at DMC Harper University Hospital, performed the breakthrough procedure with two heart patients in late February.

The two CVI patients who received the new aortic valves are among more than 300,000 people worldwide (100,000 in the U.S.) now struggling with aortic valve stenosis.  That often-disabling condition, usually caused by narrowing of the valve and resulting restriction of blood flow from the heart to the body, typically develops by age 50-70 and progresses with advancing age.

Until the recent development of the TAVI system, however, the only therapeutic alternative for patients with stenosis was open-heart surgery.

Dr. Schreiber, who was also a pioneer in developing the stent procedure for relieving blocked carotid arteries, said that the results of the just-released ACC study, organized and administered by a team of interventional cardiologists and cardiac surgeons at Columbia University, provides "powerful scientific evidence that non-invasive catheterization is superior to open-heart surgery among older patients."  

Physicians are available for interviews.

About Detroit Medical Center

The Detroit Medical Center operates nine hospitals and institutes, including Children's Hospital of Michigan, Detroit Receiving Hospital, Harper University Hospital, Huron Valley-Sinai Hospital, Hutzel Women's Hospital, Rehabilitation Institute of Michigan, Sinai-Grace Hospital, DMC Surgery Hospital, and DMC Cardiovascular Institute. The Detroit Medical Center is a leading regional healthcare system with a mission of excellence in clinical care, research and medical education.

SOURCE Detroit Medical Center
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Aspirin Named 8th World Wonder by Majority of Americans
2. Xeloda XeNA Study Analyses of Xeloda, Docetaxel and Herceptin Combination Therapy for Metastatic Breast Cancer Featured at Major New Breast Cancer Symposium
3. Xeloda(R) XeNA Study Analyses of Xeloda, Docetaxel and Herceptin Combination Therapy for Metastatic Breast Cancer Featured at Major New Breast Cancer Symposium
4. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
5. ArtJen Announces Major Clinical Trial of Its Patented Weight Loss Product FBCx
6. deCODE Launches deCODE MI(TM) -- A Test for a Major Genetic Risk Factor for Early-onset Heart Attack
7. EnVivo Pharmaceuticals Announces Progress on Major Drug Programs Focusing on Alzheimers, Schizophrenia and Huntingtons Diseases
8. Abbotts XIENCE(TM) V Everolimus Eluting Coronary Stent Shows Continued Superiority to TAXUS Stent in Reducing Major Adverse Cardiac Events in SPIRIT III Clinical Trial
9. Results of VYVANSE(TM) (lisdexamfetamine dimesylate) Pivotal Trial in Adult ADHD Presented at Major Scientific Meeting
10. Results Of VYVANSE(TM) (lisdexamfetamine dimesylate) Effect Size Analysis Presented at Major Scientific Meeting
11. Fabre Kramer Pharmaceuticals Receives Decision From FDA on Gepirone ER for Major Depressive Disorder
Post Your Comments:
(Date:10/13/2015)... 8, 2015 Research and Markets ( ... Anti-counterfeit Pharmaceuticals and Cosmetics Packaging - Market Opportunities and ... --> --> ... at a CAGR of 15.7% during 2015-2020 ... technology segment accounted for about 52% share in 2014 ...
(Date:10/12/2015)... the United States . By early next ... --> the United States . By early next ... --> The University of Texas MD Anderson Cancer Center, Elekta ... (1.5 Tesla) MRI-guided linear accelerator in the United States ... in a non-clinical capacity. Royal Philips (NYSE: ...
(Date:10/12/2015)... COSTA MESA, Calif. , Oct. 12, 2015 ... reaffirmed the accreditation of Harbor Compounding Pharmacy in ... accreditation is awarded in recognition of the pharmacy,s ... --> ... --> ...
Breaking Medicine Technology:
(Date:10/13/2015)... GA (PRWEB) , ... October 13, 2015 , ... ... nonprofit promoting the establishment of telemedicine programs in communities throughout Georgia, along with ... announce the collective schedule for their regional telehealth summits for Fall 2015. ...
(Date:10/13/2015)... ... October 13, 2015 , ... According to an ESPN ... orbital fracture when a teammate accidentally elbowed him in the left eye during the ... injury is just one of a series of setbacks, including a knee injury that ...
(Date:10/13/2015)... ... October 13, 2015 , ... In an ... PediaPlex , a Southlake, Texas, child development and pediatric therapy center, is ... educating military families about their options for receiving this kind of care for ...
(Date:10/13/2015)... Niguel, CA (PRWEB) , ... October 13, 2015 ... ... tools, announced the release of a new PDF automation tool to batch ... regulations, and business mandates with 100% document fidelity. , CADConverter eliminates the complexity ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... winning programs Elder Care Doula Training and End of Life Doula Training. ... a holistic model, physically, spiritually and emotionally. Based on her #1 International ...
Breaking Medicine News(10 mins):