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Major Clinical Study Supports NIPT As First Line Screening Test For All Pregnant Women
Date:8/13/2014

SAN CARLOS, Calif., Aug. 13, 2014 /PRNewswire/ -- Natera, Inc., a leader in non-invasive genetic testing, today announced a study to be published in the November issue of American Journal of Obstetrics and Gynecology, which shows that Panorama™ NIPT performs consistently well in all pregnant women, regardless of their prior risk level. This is the largest ever published study of clinical outcomes with NIPT, following more than 17,000 consecutive cases originally analyzed by Natera in mid-2013. It is also the second in a series of published studies showing strong test performance in low risk populations.

"This study supports the use of NIPT as a first line screening test for aneuploidy," said lead author Peer Dar, MD, Head of Fetal Medicine at Montefiore Medical Center in New York. "These results are consistent with recent NIPT guidelines published by the American College of Medical Genetics and Genomics (ACMG) that do not distinguish between high risk and low risk pregnancies, and which recommend NIPT in conjunction with first trimester ultrasound."

Key findings of this study:

  • Performance of the Panorama NIPT, determined previously in published case-controlled validation studies, has now been confirmed in a clinical setting with this study, the largest clinical outcomes study of NIPT to date. 
  • NIPT is already being adopted by some low-risk women and their healthcare providers, with 49% of the cases in this clinical study from women under 35 years of age.
  • The authors find that there are no concerns about performance of NIPT as a first line screen, and it will be accessibility and affordability that determine universal adoption.
  • The study highlighted an important performance metric: positive predictive value (PPV). Panorama's demonstrated PPV is significantly
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SOURCE Natera, Inc.
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