MacuSight(TM) Announces Positive Preliminary Results From Phase 1 Study of Sirolimus in Wet Age-Related Macular De...(ounced Phase 1 data for our sirolimus pr...),Health

Date:2/25/2008

ounced Phase 1 data for our sirolimus product in patients with diabetic macular edema," stated Joel Naor, M.D., chief medical officer of MacuSight. "Based on the positive findings from both our wet AMD and DME studies, we are preparing to initiate Phase 2 trials in both of these important indications, as well as additional ocular diseases and conditions."

MacuSight intends to complete its collection and analysis of all data from its wet AMD trial and present final findings at the Retinal Physician Symposium in Naples, Florida in May 2008.

About Sirolimus

Sirolimus, originally known as rapamycin, is a highly-potent, broad-acting compound that has demonstrated the ability to combat disease through multiple mechanisms of action including immunosuppressive, anti-angiogenic, anti- migratory, anti-proliferative, anti-fibrotic and anti-permeability activity. Based on the versatility associated with these multiple mechanisms of action, MacuSight believes that its sirolimus product may serve as a potentially highly-efficacious therapeutic for a wide range of ocular diseases and conditions, including the treatment and prevention of wet AMD.

As the active pharmaceutical ingredient in the FDA-approved products Rapamune(R) and CYPHER(R) Sirolimus-eluting Coronary Stent, sirolimus has been safely administered to humans for more than eight years. MacuSight has developed a proprietary minimally-invasive, sustained administration approach for its novel liquid sirolimus formulation which it believes will provide the product with significant competitive advantages related to convenience, ease- of-use, compliance and safety.

About Wet Age-Related Macular Degeneration (AMD)

Age-related macular degeneration (AMD) is the leading cause of visual loss in the western world. This disease of the aging eye results in loss of the sharp, central vision that is necessary for clearly seeing objects and undertaking routine tasks including reading and driving
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SOURCE MacuSight, Inc. Copyright©2008 PR Newswire. All rights reserved

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