Navigation Links
MacroChem Announces Presentation of Pexiganan Phase 3 Study Results for Topical Treatment of Diabetic Foot Infection
Date:3/13/2008

Combined data from two Phase 3 trials show clinical success rates

statistically equivalent to oral antibiotic therapy

WELLESLEY HILLS, Mass., March 13 /PRNewswire-FirstCall/ -- MacroChem Corporation (OTC Bulletin Board: MACM) announced today the presentation of a poster entitled "Topical versus Systemic Antimicrobial Therapy for Treating Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double-Blinded, Multicenter Trial of Pexiganan Cream." The poster will be presented at the Diabetic Foot Global Conference 2008 in Los Angeles on March 13 to 15 by Benjamin A. Lipsky, MD, FACP, FIDSA, Professor of Medicine, University of Washington and Director, Primary Care Clinic, VA Puget Sound Health Care System.

The poster presents results of two Phase 3 clinical studies, individually and combined, comparing the efficacy of an investigational topical antimicrobial peptide preparation, pexiganan acetate cream, against systemic therapy with an oral fluoroquinolone antibiotic, ofloxacin, for mildly infected diabetic foot ulcers. The authors conclude, in part, that, "The rates of clinical cure or improvement (the primary outcome of the trial) for topical pexiganan and oral ofloxacin were statistically equivalent for the combined studies."

Dr. Lipsky commented that, "To my knowledge, these combined studies are the largest on treatment of diabetic foot infections ever conducted, the only ones that have compared these two routes of therapy, and the first to demonstrate the efficacy of a topical antimicrobial in treating diabetic foot infection in active-controlled trials. Furthermore, having an effective topical therapy available as an alternative to systemic treatment focuses attention on the wound and, in the case of pexiganan, uses a new antimicrobial, while avoiding adverse systemic effects and the promotion of antibiotic resistance."

"We are very pleased that these newly analyzed data are being presented for the first time a
'/>"/>

SOURCE MacroChem Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. MacroChem Acquires Rights to Pexiganan, a Novel Topical Anti-Infective for Treatment of Diabetic Foot Infections, From Genaera
2. Synbiotics Corporation Announces Human Submission for FluDetect(R)
3. Raven Announces Initiation of a RAV12 Phase 2 Clinical Trial in Metastatic Pancreatic Cancer
4. Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights
5. Progen Announces Commencement of Global Phase 3 Study for PI-88 in Post- Resection Liver Cancer
6. Inclinix Announces New Patent for Expert System Platform
7. Genzyme Announces Presentation of New Positive Data on Carticel(R)
8. Keryx Biopharmaceuticals Announces that the SUN-MICRO Phase 3 Clinical Trial Failed to Meet its Primary Efficacy Endpoint
9. AlphaMed Pharmaceuticals Announces Breakthrough in the Development of Recombinant Alpha 1-Antitrypsin
10. Transgenomic Announces New Contracts for Phase II Trials With Two Major Pharmaceutical Companies
11. HUYA Bioscience Intl Announces World-Class Clinical Advisory Team for New Anti-Arrhythmic Compound Sourced From China
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... LAVAL, Quebec , July 10, 2014  Valeant ... TSX: VRX) today announced it has completed the sale ... Sculptra, and Dysport owned or held by Valeant for ... agreement with Nestle S.A, which recently completed its acquisition ... complete the divestiture of our products to a company ...
(Date:7/10/2014)... Israel , July 10, 2014   ... Diabetes Management Solution, today announced the appointment of ... independent member of its Board of Directors. ... legal and business experience to LabStyle as an ... and legal and corporate governance expert. He currently ...
(Date:1/15/2014)... 15, 2014 Sono-Tek Corporation (OTC BB: SOTK) today announced ... 2013, compared to sales of $2,202,000 for the prior year ... quarter has also shown growth over the preceding quarter,s sales, ... this fiscal year. Markets that experienced sales increases over the ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4
... Baxa Corporation, a leading,provider of systems for safe ... addition of two new international product,distributors. These agreements ... Pentafarma & Co. in The Dominican Republic -- ... expand product promotion in South,America and the Caribbean. ...
... Design ... and Test AIDS Vaccines, NEW YORK, Sept. ... from Executive Director,Mitchell Warren about the announcement that vaccinations have been,discontinued ... candidate developed by the Merck Research Laboratories: "Today,s announcement about ...
Cached Medicine Technology:Baxa Corporation Extends Global Reach With New Distribution Agreements in Colombia and the Dominican Republic 2AIDS Vaccine Advocacy Coalition Voices Disappointment in Trial Result 2AIDS Vaccine Advocacy Coalition Voices Disappointment in Trial Result 3
(Date:7/10/2014)... "Mississippi baby" an infant seemingly cured of HIV that ... of HIV infection in The New England Journal of ... more than two years of not taking antiretroviral therapy without ... researchers involved in the case. , "Certainly, this ... the medical staff involved in the child,s care, and the ...
(Date:7/10/2014)... Mich. For those students looking to bump up ... not be spending more time in a library or ... State University research shows that students who were members ... campus during their freshman and sophomore years had higher ... also indicated that students with memberships stayed in school ...
(Date:7/10/2014)... Minn. The benefits of medical imaging far outweigh ... The Right Way, with The Right Radiation Dose. However, ... and Mayo Clinic is leading a collaborative effort to ... commentary, published online in the Journal of Patient ... the Joint Commission, the Intersociety Accreditation Commission, and the ...
(Date:7/10/2014)... shown that more severe illness and even death are ... infection after developing influenza. Now, however, a team of ... if you reverse the order of infection, the bacteria ... protect against a bad case of the flu. ... which is described as a bacterial virulence factor, might ...
(Date:7/10/2014)... brain operates much the same whether active or at ... understanding of schizophrenia, bipolar disorder and other serious mental ... , In newly published research in the journal ... Center for Molecular and Behavioral Neuroscience, determined that the ... basically the same as that of a person performing ...
Breaking Medicine News(10 mins):Health News:'Mississippi Baby' now has detectable HIV, researchers find 2Health News:'Mississippi Baby' now has detectable HIV, researchers find 3Health News:Want a higher GPA in college? Join a gym 2Health News:Mayo Clinic calls for standardization of safe imaging protocols for children 2Health News:Bacterial colonization prior to catching the flu may protect against severe illness 2Health News:Working to loosen the grip of severe mental illness 2
... Carlton Turner as Chairman, Robert Schnitzius as Acting President & CEO ... 11 DelSite, Inc. (OTC Bulletin Board: DSII.OB), a drug delivery ... of directors for the Company, has resigned his position as chairman, ... board until his term ends in May 2009. , ...
... BUFFALO, N.Y. -- Using the bells and whistles of ... School of Education project aims to improve the driving ... risk pool, and at the same time bring child ... The population identified as risky drivers: teenagers with ADHD ...
... DreamPak Nutritional Supplements,has developed a new revolutionary appetite and ... suppress their desire to eat,and reduce their food intake, ... eat less but still feel satisfied. Additionally, Trimma(TM),comes in ... to,satisfy their chocolate and sweet cravings. , ...
... Well at 100! , , WEST ... celebrated her 100th birthday. This year, to her great joy, she was ... a partial corneal transplant that has a much shorter recovery time than ... New Jersey. , , Katherine, who ...
... the adult heart is unable to regenerate. Now, researchers ... Medicine (MDC) Berlin-Buch and the Charit Universittsmedizin Berlin ... no longer holds true. Dr. Laura Zelarayn and Assistant ... that the body`s own heart muscle stem cells do ...
... Holidays are always fraught with,tension. This year, with the country ... maintain holiday cheer. While they won,t change the,economy, a ... they need this holiday season. , ... , Six Seconds is ...
Cached Medicine News:Health News:DelSite Chairman George DeMott Resigns 2Health News:DelSite Chairman George DeMott Resigns 3Health News:UB driver simulation study targets high-risk teenage drivers 2Health News:UB driver simulation study targets high-risk teenage drivers 3Health News:Trimma(TM) Now Available in the United States for People Looking for a Delicious Way to Control Their Calories 2Health News:Centenarian's Vision Restored With New Sutureless Corneal Transplant Technology 2Health News:Heart regenerates after infarction -- first trials with mice 2Health News:Holiday Cheer or Holiday Fear? Free Resource for a Happier Holiday 2
Inquire...
Inquire...
... Before TOPscan Dispensers used to only have two ... process the completed job at a wholesale lab, ... The alternative was to finish the order in ... additional offices required another edger, lens inventory, more ...
Inquire...
Medicine Products: