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MabVax Therapeutics Receives $1,750,000 Small Business Innovation Research Contract Award From The National Cancer Institute To Support Development of Novel Pancreatic Cancer Diagnostic Imaging Agent
Date:9/24/2013

eutics has generated fully human monoclonal antibodies against sLea with unusual high affinity for this carbohydrate ligand.  MabVax discovered the 5B1 anti-sLea antibody from a patient who was vaccinated with a sLea anti-cancer vaccine. 

While the intact 5B1 antibody shows promise as a PET imaging agent in an animal model, the use of antibody fragments (5B1 diabodies) is expected to provide additional benefits over intact 5B1.  The 5B1 diabody is expected to show increased clearance from negative tissues and increased tumor retention thereby increasing the signal-to-noise ratio and tumor specificity.  A shorter half-life (i.e. days vs. weeks) also allows clearance of tracers within 1-2 weeks and facilitates unobstructed repeat imaging with the same agent.

There is a clear need for new diagnostic tools that allow earlier detection and for improved therapy regiments.  The radiolabeled 5B1 diabody represents the only human derived agent in development specifically aimed at improving imaging in pancreatic cancer.  Since the antigen targeted by the 5B1 diabody is significantly and preferentially over expressed on metastatic pancreatic cancer, this development effort represents a potentially important step forward in the diagnosis, staging, and assessment of the majority of pancreatic cancer patients.  The company believes that the market opportunity for a 5B1 diabody-based radiopharmaceutical is significant.  The ability of physicians to accurately diagnose, stage, and assess treatment outcomes in pancreatic cancer would be very important.  Additionally, accurate determinations on extent of disease and resectability are essential to improve outcomes in this cancer.  Patients diagnosed with pancreatic cancer could benefit from scans conducting with this new product because of the improvement in the sensitivity and specificity of this key diagnostic tool resulting in a signi
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SOURCE MabVax Therapeutics, Inc.
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