Navigation Links
MJFF's Rapid Response Innovation Awards Hit Mid-2009 With Over $1 Million Funded in High-Risk/High-Reward Approaches to Parkinson's Disease
Date:6/25/2009

NEW YORK, June 25 /PRNewswire-USNewswire/ -- As of mid-2009, The Michael J. Fox Foundation for Parkinson's Research has already funded over $1 million in high-risk, high-reward approaches to Parkinson's therapeutic development through its groundbreaking Rapid Response Innovation Awards. Projects include investigations of the safety and efficacy of an FDA-approved drug for kidney disease to treat Parkinson's; characterization of a tenuous link between PD and certain strains of influenza virus; and a proof-of-principle approach to refine deep brain stimulation (DBS) into a potentially more effective symptomatic therapy.

Rapid Response, one of the Foundation's Edmond J. Safra Core Programs for PD Research, earmarks up to $2 million annually to support research with little to no existing preliminary data, but potential to crack open entirely new ways of understanding or treating Parkinson's disease. The program has no deadline, instead accepting researchers' proposals on a rolling basis throughout the year in order to fund truly novel thinking whenever inspiration strikes.

"Rapid Response enables us to assess the best new ideas in real time, quickly vet their potential, and move the most promising ones to the next level fast," said Katie Hood, CEO of MJFF. "This reflects our commitment to keep fresh ideas flowing into the Parkinson's therapeutic pipeline, as well as our recognition that when great research ideas have to wait for a program deadline, so do PD patients -- a status quo we are determined to improve on."

Highlights of the 2009 program include:

  • Curt R. Freed, MD, of the University of Colorado has discovered that phenylbutyrate, a drug already approved by the U.S. FDA to treat kidney disease, prevents brain deterioration in pre-clinical models of Parkinson's. The drug may turn on a protective gene called DJ-1 in the brain. Dr. Freed is studying 12 people with recently diagnosed PD to determine if the drug can increase DJ-1 levels and set the stage for determining whether phenylbutyrate may slow disease progression.
  • Richard Smeyne, PhD, of Saint Jude Children's Research Hospital will test the hypothesis that the virulent H5N1 ("bird flu") strain of influenza virus can play a role in inducing parkinsonism. There is significant literature, mostly based on cases from the Spanish Influenza outbreak of 1918, documenting Parkinson's disease following exposure to flu virus. The researchers hypothesize that flu can induce aspects of PD including cell loss, as well as to show how viruses access the nervous system.
  • Wassilios Meissner, MD, PhD, of University Hospital Bordeaux (France) and Peter Tass, MD, PhD, of the University of Cologne (Germany) want to update deep brain stimulation surgery, taking advantage of new discoveries about the mechanisms of PD to expand DBS's benefit to a wider range of PD patients. With MJFF funding, they are working in a pre-clinical model of PD to assess the practical potential of modifying abnormal synchronization in the brain's basal ganglia region -- an approach that, according to preliminary theoretical studies, could result in functional improvements for PD patients.

The Foundation has funded 20 Rapid Response Innovation Awards in 2009, and a total of $6,081,627 in awards since the program was first launched. Some Rapid Response projects from prior years have gone on to garner major additional funding to support the next stage of research, including clinical trials. These include D. James Surmeier, PhD's 2007-2008 investigation of approved high-blood pressure drug isradipine as a neuroprotective approach to PD, which is currently being tested with MJFF support in a Phase 2 controlled clinical trial.

The Michael J. Fox Foundation is dedicated to ensuring the development of better treatments, and ultimately a cure, for Parkinson's disease through an aggressively funded research agenda. MJFF has funded over $143 million in research to date.


'/>"/>
SOURCE Michael J. Fox Foundation
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Siemens Corporate Research Develops RAPID2 System for Fast Discovery of Discriminative Pathogen Signatures
2. RAPAFLO(TM) (silodosin) Provides Rapid and Sustained Benign Prostatic Hyperplasia (BPH) Symptom Relief in as Little as Three Days
3. Arrayit to Mass Produce Rapid H1N1 Swine Flu Test Chip
4. CyberKnife Radiosurgery for Lung Cancer Sees Increased Interest and Continued Rapid Growth
5. MicroPhage Successfully Completes Beta Trial for Rapid MRSA Test
6. Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia
7. FDA Approves Rapid-Acting Insulin Apidra(R) for Treatment of Children with Diabetes
8. CIMZIA(R) (Certolizumab Pegol) Provides Rapid and Sustained Relief from Signs and Symptoms of Rheumatoid Arthritis for Two Years
9. Technique for Rapidly Reprogramming Adult Cells Into Stem Cells Published in PLoS Biology
10. Walter Reed Evaluation Concludes FirstVue(TM) HBSAG Test is Preferred over Other Rapid Tests
11. Novel Photoconductive Life Science Research Innovation Enables Rapid, Reproducible, and Non-Invasive Cellular Excitation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains ... possible to save lost souls in the Philippines. “The Journey: From the Mountains to ... dedicated teacher of the Bible. She has taught all ages and currently teaches a ...
(Date:10/12/2017)... Del. (PRWEB) , ... October 12, 2017 , ... ... and advisory services for healthcare compliance program management, will showcase a range of ... National Association for Assisted Living (NCAL) Convention and Expo to be held October ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Planet Fitness, ... the U.S., announced today its plans to open a flagship location in Covington, LA ... the former Rooms To Go store next to Office Depot in the Holiday Square ...
Breaking Medicine News(10 mins):