Navigation Links
MDS Patients on Five-Day Vidaza(R) Dosing Schedules Achieve Transfusion Independence Consistent with Seven-day Schedule
Date:12/11/2007

ndromes (MDS)" (Abstract #819).

In this Phase 2 prospective, multi-center, randomized, open-label 3-arm trial, a total of 151 MDS patients were randomized to one of three regimens administered subcutaneous every four weeks for six cycles: Vidaza 5-2-2 (75 mg/m2/day x 5 days, two days off therapy, two additional days at same dose as the first five days; N=50); Vidaza 5-2-5 (50 mg/m2/day x 5 days, followed by 2 days off therapy and five additional days at the same dose as the first five days; N=51); Vidaza 5 (75 mg/m2/day x 5 days; N=50). The majority of patients (57 percent) were classified with FAB low-risk disease (RA/RARS), while 33 percent had FAB higher-risk MDS (RAEB/RAEB-T).

"These trial data suggest that transfusion dependency is reduced with five-day dosing schedules," said Dr. Lyons. "This could succeed in normalizing cytopenias and improve the daily lives of these patients."

The study, which is ongoing, includes this preliminary analysis of the first six cycles of therapy. Across the three alternative dose regimens, between 44 and 55 percent of evaluable patients experienced HI, defined as major or minor in at least one cell line (erythroid, platelet, or neutrophil). This reflects HI of 44, 52, and 55 percent in the Vidaza 5-2-2, Vidaza 5-2-5, and Vidaza 5 arms, respectively.

Further, across the three alternative dose regimens, between 55 and 63 percent of patients who were red blood cell (RBC) transfusion dependent at baseline achieved transfusion independence. This reflects overall RBC transfusion independence rates of 55, 60, and 63 percent in the Vidaza 5-2-2, Vidaza 5-2-5, and Vidaza 5 arms, respectively. Among transfusion-dependent patients with FAB low-risk disease, RBC transfusion independence was achieved by 60, 56, and 61 percent, respectively.

Each dosing schedule offered a safety profile similar to the well- established profile seen with standard Vidaza dosing. No treatment-related mortalities were reported. M
'/>"/>

SOURCE Pharmion Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
3. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Sixty-One Percent of Newly Diagnosed Parkinsons Disease Patients Do Not Receive Any Drug Treatment in the First Year of Diagnosis
7. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
8. Many Heart Attack Patients Dont Get Best Emergency Treatment
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. Phase 2a Multi-Dose Study Initiated by MedImmune in Patients With Asthma to Further Expand Anti-Interleukin-9 Program
11. MedImmune Initiates Phase 2a Multi-Dose Study in Patients with Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... N.C. , Feb. 27, 2015 The ... the past decade but one thing hasn,t changed: face-to-face ... to build relationships with Key Opinion Leaders. ... as the most valuable type of interaction, field medical ... on their KOL interactions. This is just one of ...
(Date:2/27/2015)... WASHINGTON , Feb. 27, 2015  Following ... Means Committee that moved H.R. 284, the Medicare ... the American Association for Homecare (AAHomecare) released a ... quick action to pass the legislation. ... in the House Ways and Means Committee is ...
(Date:2/27/2015)... , Feb. 27, 2015 An aggressive ... helped cut the rate of infection with a dangerous ... percent. Clostridium difficile, or C.diff, is a ... life-threatening inflammation of the colon. A recent article in ... Clostridium difficile Infection in the United States ...
Breaking Medicine Technology:Improving the Management of MSL Teams to Create Value across a Diverse Set of Customers 2Bidding Fix Takes Major Step Forward After Bipartisan Vote of House Ways and Means Committee 2Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 2Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 3
... , HUNTERSVILLE, N.C., Nov. 30 Microban International, ... is pleased to announce their exclusive North America partnership ... of ceramic tile and natural stone. Dal-Tile Corp ... OutStand Technology(TM) featuring Microban(®) patent pending silver based technology, ...
... , , PRINCETON, N.J., Nov. 30 ... will present at the Piper Jaffray 21st Annual Health Care Conference ... may access a live webcast of the presentation at www.covance.com ... please log on 10 minutes early. , Covance, with headquarters in ...
Cached Medicine Technology:Dal-Tile Corp. Launches Two New Lines of Ceramic Tile with Microban(R) Silver Antimicrobial Technology 2
(Date:3/1/2015)... ERISAPros is pleased to announce ... the professional staff of its Compliance Department. , Evelyn ... State University-Mortiz College of Law. Prior to joining ERISAPros, ... several Fortune 500 companies as well as several privately ... Her experiences range from benefit plan design, vendor management, ...
(Date:2/28/2015)... Santa Cruz, california (PRWEB) February 28, 2015 ... an ever growing number of practicing physicians as a way ... experience, training or education regarding Cannabis as medicine. Since the ... have been very few resources available to licensed physicians ... treatment to a patient. Dr. Deborah Malka in Santa ...
(Date:2/28/2015)... Calgary, AB (PRWEB) February 28, 2015 ... and is now a distributor of the machine. The ... part of their license, like a franchise model. The ... people prevent and reverse heart disease. To buy ... Heart Fit Clinic can help individuals through this process ...
(Date:2/28/2015)... Indosoft Inc , developers of Q-Suite, ... pleased to announce the development of Q-Suite 5.9. Building ... of Q-Suite, this new version will include enhancements to ... features to the leading edge call center software. General ... add features to enhance security and protection. Administrators will ...
(Date:2/28/2015)... 28, 2015 National Sales ... sales, marketing and supply chain management for consumer ... is bringing its award winning solutions for thinning-damaged ... products are specifically created to combat thinning-damaged hair. ... is committed to marrying science with nature to ...
Breaking Medicine News(10 mins):Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2Health News:Reputable Cannabis Doctor In Santa Cruz and Monterey Joins the Medical Cannabis Network 2Health News:Clinicians Can Now Purchase External Counterpulsation with Heart Fit Clinic 2Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 3
... Company) (NYSE: BDX ), a global medical technology company,announced today that ... 2008 Annual Credit Suisse Healthcare Conference ... pm ET, Lazard Capital Markets 5th Annual ... 10:55 a.m. ET, A live webcast of BD,s ...
... (human papillomavirus) vaccines and the validation of a simple oral ... studies by a Johns Hopkins Kimmel Cancer Center investigator. , ... identify HPV infection as the cause of certain oral cancers ... risk factor for these cancers, reports her latest work in ...
... Taking Medications for Blood Pressure, Cholesterol, ... Asthma, ADD/ADHD, Depression and Diabetes, ST. LOUIS, Nov. 3 ... type 2 diabetes medications between 2002 and,2005, with girls between ... One likely cause: Obesity, which is closely associated with type,2 ...
... Declared, ACTON, Mass., Nov. 3 Psychemedics Corporation,(Nasdaq: ... for the,period ended September 30, 2008. The Company also ... shareholders of record as of,December 3, 2008 to be ... 49th consecutive quarterly dividend., The Company,s third quarter ...
... Robbins & Myers, Inc.,(NYSE: RBN ) announced ... Conference on November 11, 2008. The Company will be ... and Christopher,M. Hix, Vice President and Chief Financial Officer., ... CST, at,the Four Seasons Hotel in Chicago, Illinois. It ...
... Leading Cause of Death in U.S., SWANTON, Vt., ... Month, to help raise awareness about Chronic,Obstructive Pulmonary Disease ... will be making downloadable,tips available to COPD patients on ... November newsletter and blogs to raising awareness,about this 4th ...
Cached Medicine News:Health News:Research indicates need for effective HPV vaccine for women and men and a simple HPV screening test 2Health News:Research indicates need for effective HPV vaccine for women and men and a simple HPV screening test 3Health News:Tweens and Teens Double Use of Diabetes Drugs 2Health News:Tweens and Teens Double Use of Diabetes Drugs 3Health News:Tweens and Teens Double Use of Diabetes Drugs 4Health News:Psychemedics Corporation Announces Third Quarter Results 2Health News:Psychemedics Corporation Announces Third Quarter Results 3Health News:Psychemedics Corporation Announces Third Quarter Results 4Health News:Psychemedics Corporation Announces Third Quarter Results 5Health News:AllerAir Dedicates November to COPD Awareness Month 2
... Alternative to Bottled Water, The Simplicity personal ... laboratories that currently use bottled water. In ... ship and store bottled water, your laboratory ... contamination can be absorbed from containers and ...
... Produces up to 12 L/min of ... Quality On Demand, The Super-Q Plus System ... to water which has been pretreated by ... systems consistently produce ultrapure water quality which ...
... UniBloc weighing mechanism for speed, stability ... control, analog display modes, multiple units ... measure functions, auto print, and GLP/GMP/ISO ... from built-in clock. Built-in, motor-driven ...
TOPLOAD 320/0.01G, BL320S. Touch-key external calibration only. Requires calibration weights (either 200g or 300g). 120/240V A/C adapter, Lock-down Ring, In-use Protective Cover....
Medicine Products: