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MD Bioproducts releases HLA-B27 subtype specific antibody.
Date:5/29/2012

ST. PAUL, Minn., May 29, 2012 /PRNewswire-iReach/ -- MD Bioproducts launches a new subtype specific antibody as a marker for ankylosing spondylitis (AS): HLA-B*2705. The anti-HLA-B*2705 antibody, clone MARB4, has been validated for use in flow cytometry, tissue staining and immunoprecipitation.

(Photo:  http://photos.prnewswire.com/prnh/20120529/CG15198)

Ankylosing spondylitis (AS) is a chronc inflammatory arthritis. It is characterized by inflammation of the joints between the spinal bones and the joints between the spine and pelvis. It is a long term conditin where the affected joints may fuse together causing a significant loss of quality of life. The pathogenesis of AS remains highly unresolved. While it is known that HLA-B27 is strongly associated with AS, there is subtype variability with a particularly strong association with HLA-B*2704 and HLA-B*2705, which might be due to differential rates of folding. Human leukocyte antigens (HLA) play a central role in the immune system recognizing self from non-self. It is also known that endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms are associated with AS. ERAP1 is an aminopeptidase resident in the edoplasmic reticulum (ER) functioning in N-terminal peptide trimming for pHLA presentation.

The MARB4-reactive population of HLA-B27 molecules appears to be generated particularly when the activity of the ER aminopeptidase ERA
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SOURCE MD Bioproducts
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