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MAP Pharmaceuticals Reports Positive Results From Phase 2a Clinical Trial of Combination Therapy in Adult Asthmatics
Date:4/7/2008

formoterol combination product. The study also examined the consistency and efficiency of the Tempo inhaler in asthmatic patients.

The trial compared two different emitted doses of MAP0005, 104/5.4 mcg and 312/16.2 mcg of budesonide/formoterol with the 160/9 mcg dose of the commercially marketed combination product. Maximum change in forced expiratory volume in one second (FEV1) was similar for all three treatments, as was time to maximum change in FEV1. Plasma levels of budesonide were dose proportional for MAP0005. No serious or unexpected adverse events were reported in the study, and MAP0005 was well tolerated. The Tempo inhaler delivered budesonide more consistently than the commercially available product across the study population.

About MAP0005

MAP0005 is a single-particle combination of budesonide, a corticosteroid, and formoterol, a long-acting beta2-agonist, delivered to the respiratory tract using MAP Pharmaceuticals' proprietary Tempo inhaler. MAP0005 uses the Company's proprietary particle technology to combine the corticosteroid and beta-agonist components into a single drug particle in a fixed, pre-specified ratio. MAP Pharmaceuticals believes this combination technology has the potential to overcome formulation and stability constraints often seen in the development and production of inhaled combination products. In addition, the Company's technology allows particles to be specifically designed to target relevant areas in the lung and to release drug at a desired rate. While MAP Pharmaceuticals does not plan to make further significant direct investment in this product candidate, it plans to evaluate partnership opportunities for further development and commercialization of MAP0005 as well as other product candidates which may utilize this technology.

About the Tempo Inhaler

MAP Pharmaceuticals is developing the Tempo inhaler, a novel pressurized metered dose inhaler that synchronizes the discharge of drug with the
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SOURCE MAP Pharmaceuticals, Inc.
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