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M. D. Anderson to Initiate Clinical Validation Study on Rosetta Genomics' MicroRNA-based Diagnostic Assay Identifying the Origin of Cancer Metastases
Date:8/11/2008

reatment is often empiric with a "trial and error" approach. In the era of rapidly growing effective cytotoxic and targeted therapies for known cancers, quicker and more accurate methods of identifying the tissue of origin of CUP cases would permit the use of these therapies, thereby improving the chances of achieving a response and possibly extending the patient's survival.

"The current gold standard diagnostic evaluation for CUP consists of a careful history and physical examination, laboratory tests, imaging studies, invasive studies when necessary, and thorough pathologic evaluation. This process is lengthy and exposes the patient to unnecessary toxicities," noted Dr. Gauri Varadhachary (M.D. Anderson - Please insert title). "Rosetta Genomics' microRNA-based CUP assay may present an alternative test to current diagnostic practices. This study aims to validate their assay as well as compare its performance with current tests for CUP."

About microRNAs

MicroRNAs (miRNAs) are recently discovered, naturally occurring, small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by the abnormal activity of proteins, the ability to selectively regulate protein activity through microRNAs could provide the means to treat a wide range of human diseases. In addition, microRNAs have been shown to have different expression in various pathological conditions. As a result, these differences may provide for a novel diagnostic strategy for many diseases.

About Rosetta Genomics

Rosetta Genomics (Nasdaq: ROSG) is a leader in the field of microRNAs. Founded in 2000, the company's integrative research platform combining bioinfor
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SOURCE Rosetta Genomics Ltd
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