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Luminex Announces Commercial Launch of New Cystic Fibrosis Test
Date:8/26/2010

nt, it can affect people of any race or ethnicity.  

CF is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene.  To date, more than 1,500 of these mutations have been discovered(i).  CF can only be passed onto a child when both parents carry a gene that causes the disease.  According to the Cystic Fibrosis Foundation, more than 10 million Americans are symptomless carriers of CF-causing gene mutations.  

Early diagnosis of CF is important and studies have demonstrated that early treatment and intervention can reduce a child's therapeutic needs, lower rates of medical complications, increase life expectancy and improve overall quality of life. Late diagnosis of cystic fibrosis can lead to health complications, chronic lung infections and compromised growth.

The xTAG Cystic Fibrosis 60 Kit v2 can detect up to 60 CFTR gene mutations from a single patient blood sample.  These mutations include the 23 CFTR gene mutations and four variants (polymorphisms) recommended by the American College of Medical Genetics (ACMG) and American College of Obstetricians and Gynecologists (ACOG), as well as 37 additional common North American mutations, including 20 mutations that are found within Hispanic and African-American populations.

The xTAG Cystic Fibrosis 60 Kit v2 is flexible.  It gives physicians the ability to select the mutations for which they want to test, allowing them to choose to test a patient for the ACMG/ACOG-recommended gene mutations or the entire panel of 60 CFTR gene mutations.  

The test also is easy to use and requires only about one hour of hands-on time to process 48 purified samples.  Additionally, the xTAG Cystic Fibrosis 60 Kit v2 does not require reflex testing.  All test results are revealed and available for analysis at each run.  

The xTAG Cystic Fibrosis 60 Kit v2 is one of a suite of CF tests developed by Luminex.  The xTAG
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SOURCE Luminex Corporation
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