Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Huma...(ant clinical changes observed during or ...),Health

Date:8/20/2007

ant clinical changes observed during, or following dose administration of 0, 3, 10, 30 or 100 mg/kg. The few minor clinical changes observed were all considered either not related to the administration of humanized Sphingomab or not toxicologically significant. No findings were observed in clinical chemistry, hematology, coagulation or lymphocyte subpopulation measures except for a slight decrease in blood lymphocytes at the highest dose administered, and this effect could not be observed within one week after cessation of dosing.

The histopathology results from this 28-day toxicology study are expected later this quarter, but no negative findings of any significance are expected.

In conclusion, the preclinical safety profile of humanized Sphingomab was extremely favorable throughout a wide variety of studies at high multiples of anticipated human exposure.

"These are extremely encouraging results," said William Garland, Ph.D., Lpath's vice president of drug development. "The favorable findings will provide Lpath with considerable dosing flexibility in our upcoming Phase I clinical trials."

Lpath plans to file an IND in November of 2007 for clinical use of ASONEP(TM) (the systemic formulation of humanized Sphingomab) in the treatment of cancer patients. During the first quarter of 2008, Lpath plans to file a second IND, this one for clinical use of iSONEP(TM) (the ocular formulation of humanized Sphingomab) in the treatment of AMD patients.

Scott Pancoast, Lpath's president and CEO, commented, "The strong safety profile of Sphingomab bolsters not only our cancer program, but also our ocular program, because the drug substance is humanized Sphingomab in both cases."

About Lpath:

Lpath, Inc., headquartered in San Diego, California, is the category leader in lipidomics-based therapeutics, an emerging field of medical science whereby bioactive signaling lipids are targeted for treating important human diseases. ASONEP(TM) (the s
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SOURCE Lpath, Inc. Copyright©2007 PR Newswire.

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