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Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
Date:3/31/2008

ts, or to any ACE inhibitor or for patients taking LOTREL, amlodipine. Do not take the benazepril and HCTZ combination if you have a history of reduced urine output, or have allergic reactions to certain drugs known as sulfonamides and tell your doctor if you have liver problems, lupus or if you take lithium. Your doctor or pharmacist can give you a complete list of the ingredients in LOTREL or the benazepril and HCTZ combination.

In rare cases with LOTREL or the benazepril and HCTZ combination, a potentially life-threatening allergic reaction (swelling of the mouth and throat) can occur. This potentially dangerous swelling of the mouth and throat has been reported more often in African American patients receiving ACE inhibitors than in non-African American patients.

The most serious side effect with LOTREL and the benazepril and HCTZ combination is low blood pressure.

The most common side effects in patients taking LOTREL and the benazepril and HCTZ combination include cough, dizziness, and headache, additionally with the benazepril and HCTZ combination fatigue and additionally with LOTREL, edema (swelling of the feet, ankles, legs, or hands).

Please see full prescribing information about Lotrel and Lotensin HCT at http://www.pharma.us.novartis.com or contact Christine Cascio at 862-778-8026 or christine.cascio@novartis.com. The combination doses of benazepril and HCTZ

40/12.5 mg and 40/25 mg used in this study were investigational and do not have approved prescribing information available.

About high blood pressure and treatment

High blood pressure increases a person's risk of experiencing a cardiovascular event. For example, it has been reported that the risk of heart attack and stroke doubles with every 20/10 mmHg increase in blood pressure, starting at 115/75 mmHg. Blood pressure treatment guidelines s
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SOURCE Novartis Pharmaceuticals Corporation
Copyright©2008 PR Newswire.
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