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Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
Date:3/31/2008

er stopping their current high blood pressure medication, patients received a single-pill combination of either Lotrel or a combination of benazepril and HCTZ. In the first two months of the study, doses of study medications were increased. Patients in the Lotrel arm started on 5/20 mg. The dose was increased to Lotrel 5/40 mg and, for patients not at goal blood pressure, then to 10/40 mg. Patients taking benazepril and HCTZ started at 20/12.5 mg and were increased to 40/12.5 mg and, for patients not at goal blood pressure, to 40/25 mg. The combination doses of benazepril and HCTZ 40/12.5 mg and 40/25 mg used in this study were investigational. In both arms, patients were given additional blood pressure medication if goal blood pressure was not attained on the maximum dose of study medications.

The primary study endpoint was a composite of cardiovascular disease, non- fatal heart attack, non-fatal stroke, and hospitalization for unstable angina (chest pain that occurs when the heart muscle does not get enough blood) or revascularization (a procedure that re-establishes blood flow to previously restricted regions of the heart), and cardiovascular death. The full data will be available later this year and further analyses will examine the effects on specific patient populations.

Important safety information

LOTREL and the fixed dose combination of benazepril and HCTZ are prescription medications for the treatment of high blood pressure. They should not be used before other high blood pressure medications have been tried first.

LOTREL and the fixed dose combination of benazepril and HCTZ can harm an unborn baby and even cause death. If you get pregnant, stop taking LOTREL or the benazepril and HCTZ combination. Call your doctor right away. Talk to your doctor about other ways to lower your blood pressure if you plan to become pregnant.

Don't take LOTREL or the benazepril and HCTZ combination if you are allergic to any of the ingredien
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SOURCE Novartis Pharmaceuticals Corporation
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