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Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
Date:3/31/2008

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Treatment with combination therapy resulted in exceptional blood pressure control at 30 months. Before entering the study, almost all patients were treated with multiple high blood pressure medicines. At study entry, only 37% of the study population had a blood pressure of <140/90 mmHg, regarded in treatment guidelines as the appropriate goal for most patients. After switching to a single-pill combination of the study medications, 82% of patients taking Lotrel and 79% of patients taking the benazepril and HCTZ combination achieved blood pressure goal after 30 months. Some patients received additional medication to treat their high blood pressure.

"Evidence from trials like ACCOMPLISH provides physicians with additional information to better inform their treatment decisions in high-risk hypertensive patients," said Marjorie Gatlin, MD, Vice President and Head of Cardiovascular and Metabolism Medical Franchise US Medical and Drug Regulatory Affairs at Novartis Pharmaceuticals Corporation. "Novartis is an innovator of unique medications for the treatment of high blood pressure, including single- pill combinations, and is committed to further develop this approach for effective patient care."

The results were presented today in a late-breaking session at the American College of Cardiology 57th Annual Scientific Session in Chicago.

ACCOMPLISH is the first large clinical outcomes trial to directly compare two single-pill combinations of commonly used high blood pressure medicines in the reduction of a composite endpoint including heart attacks, strokes, hospitalizations for unstable angina and cardiovascular deaths in high blood pressure patients at high cardiovascular risk. In October 2007, the study was stopped early because the pre-defined efficacy outcome had been achieved.

The study was a multi-national, double-blind trial and included more than 11,000 patients at 550 study sites in the US and Scandinavia. One day aft
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SOURCE Novartis Pharmaceuticals Corporation
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