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Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements (Longevinex(R)) Rather than Mega-Dose Resveratrol Alone
Date:12/27/2008

tem, says Sardi.

"We know that over-inhibition of TNF in humans increases the risk for lymphoma (cancer that originates in lymphocytes, a type of white blood cell)," says Sardi. [Therapeutics Clinical Risk Management 2007 Jun; 3(2):245-58] "When laboratory mice were given mega-dose resveratrol they did not live as long and largely succumbed to lymphoma. Resveratrol is a known TNF inhibitor," adds Sardi. [Biochemical and Biophysical Research Communications 2008 May 2; 369(2):471-7]

Confusing dosage advice

While longevity seekers have been hearing a lot about resveratrol in the past four years, since an Ivy League university discovered it activated a longevity gene known as Sirtuin 1, advice concerning dosage has been confusing at times.

A 2006 mouse study suggested consumers would have to drink about 750 to 1500 bottles of red wine a day to live longer (24 milligrams per kilogram of body weight), but the longevity effect was only demonstrated among mice engorged with a fat-laden diet (60% fat calories vs. 35% for the typical human diet), which isn't a real-world example.

When the data on mice fed a standard calorie diet were analyzed and published in 2008 [Cell Metabolism. 2008 Aug; 8(2):157-68], ultra-high dose resveratrol (360 mg and 1565 mg, human equivalent dosage) actually stunted the lifespan of mice. So the public has been misled concerning dosage since 2006 [Nature 2006 Nov 16; 444:337-42], and may have never heard about the 2008 report, says Sardi.

Lower dose resveratrol accompanied by an array of other small molecules may be superior to resveratrol alone. According to a mouse study conducted by Longevinex(R), published in the September 2008 issue of Experimental Gerontology [2008 Sept; 43(9):859-66], far more longevity genes were activated in heart tissue by Longevinex (9-fold more) than plain resveratrol, at a dose that was 17-320 times lower t
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