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Long-term Use of Antiepileptic Drug Vimpat® (Lacosamide) C-V Reduced Seizure Frequency and Severity and Improved Health-related Quality of Life Measures
Date:12/5/2011

sented at AES used the following measurement scales:

  • Quality of Life in Epilepsy scale (QOLIE-31) is an epilepsy-specific assessment with 31 questions that ask patients about their health-related quality of life.  Responses to the questions are ranked on a scale of 0 (worst possible quality of life) to 10 (best possible quality of life).
  • Seizure Severity Questionnaire (SSQ) allows patients to review various aspects of their seizures, such as altered consciousness and cognitive, emotional, and physical effects.
  • Patient Global Impression of Change (PGIC) is a scale that allows patients to rank how much they think their condition has changed during the treatment period of the trial.  The scale ranges from 0 (much better) to 10 (much worse).

Summary of Vimpat® Data:

Abstract 2.233: Evaluation of Long-Term Treatment with Lacosamide for Partial-Onset Seizures: A Pooled Analysis of Open-Label Extension Trials

This analysis of pooled data from three open-label extension trials examined the effects of open-label treatment with lacosamide exposure up to 8 years in patients with partial-onset seizures.  A total of 1,054 patients initiated open-label lacosamide treatment, representing 2,997.8 patient-years exposure.  Results showed that treatment with lacosamide up to eight years was generally well tolerated and associated with a reduction in seizure frequency and maintenance of efficacy over time.  Additionally, no new safety concerns were identified related to long-term treatment with lacosamide. 

The median modal dose of lacosamide (i.e., the dose that patients used most often during the trial) was 400mg/day for a minimum treatment duration of three days up to a maximum duration of 2,913 days (~8 years).  The median maximum daily dose was 500 m
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SOURCE UCB, Inc.
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