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Long-term Use of Antiepileptic Drug Vimpat® (Lacosamide) C-V Reduced Seizure Frequency and Severity and Improved Health-related Quality of Life Measures
Date:12/5/2011

ATLANTA, Dec. 5, 2011 /PRNewswire/ -- UCB today announced new findings for Vimpat® (lacosamide) C-V that offer additional support regarding the long-term effects of the antiepileptic drug (AED) as an adjunctive therapy for adults with uncontrolled partial-onset seizures.  The data demonstrate reduced seizure severity and improvements in measures of health-related quality of life (HRQoL).  These and other Vimpat® data were presented at the 65th Annual Meeting of the American Epilepsy Society (AES) in Baltimore, Md.

Analyses of pooled data from open-label extensions of several Phase II/III trials showed that treatment with lacosamide was generally well-tolerated and associated with decreased partial-onset seizures for up to eight years. 

"Collectively, this body of evidence showed that lacosamide reduced seizure frequency and improved health-related quality of life, as reported by patients.  And these effects were maintained over a long-term basis," said Dr. William Rosenfeld, M.D., Director, The Comprehensive Epilepsy Care Center for Children and Adults, St. Louis, Mo.

Additional analyses of pooled data from open-label extensions of several Phase II/III trials highlighted patients' self-reported improvements in HRQoL during long-term treatment with lacosamide.  Specific areas of improvements reported by patients were seizure worry and social functioning.  Patients also consistently reported feelings of improvements in their overall health state.

Vimpat® is indicated as adjunctive therapy for the treatment of partial-onset seizures in adults with epilepsy.  The most common adverse reactions reported in pivotal trials and occurring in 10 percent or more of Vimpat®-treated patients, and greater than placebo, were dizziness, headache, nausea, and diplopia.  Additional important safety information for Vimpat® is available at the end of the press release.

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SOURCE UCB, Inc.
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