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Long-term Non-invasive Positive Pressure Ventilation Treatment Delivers 76 Percent Reduction in Risk of Death at One Year among Stable COPD Patients
Date:8/4/2014

ure settings of NPPV."

Study Revealed 76 Percent Reduction in Risk of Death with NPPV InterventionThe study was an investigator-initiated, multicenter, prospective, randomized, controlled clinical trial. Starting in 2004, patients were recruited from 36 respiratory units in Germany and Austria, then hospitalized and randomized in a 1:1 ratio to one of two parallel groups and followed-up for at least one year. The control group received optimized COPD therapy and the intervention group received optimized COPD therapy plus NPPV, and was advised to use NPPV for at least six hours per day.

Researchers measured the survival of patients and found that 33 percent of patients in the control group died within one year, versus 12 percent of patients in the intervention group, a 76 percent reduction in risk of death. The survival benefit in the intervention group was maintained for longer than the year of the main study suggesting that the benefits are longer term.

To evaluate changes in health-related quality of life, researchers used three different questionnaires.  All results favored the treatment group over the control group demonstrating that the patients receiving long-term NPPV perceived themselves as healthier and less symptomatic. Researchers also conducted a six-minute walk test to evaluate exercise capacity, and found that improvements during follow-up were significantly greater in patients receiving NPPV compared with controls.

"This study aligns with our goal of improving lives with every breath," said ResMed Chief Medical Officer Dr. Glenn Richards, M.D. "COPD takes an enormous human toll, and is also a significant burden on healthcare systems, putting a higher priority on pursuing treatments that have the potential to improve survival and reduce spending for healthcare organizations worldwide."

For more information, the full study p
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SOURCE ResMed Inc.
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