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Long-term Non-invasive Positive Pressure Ventilation Treatment Delivers 76 Percent Reduction in Risk of Death at One Year among Stable COPD Patients
Date:8/4/2014

SAN DIEGO, Aug. 4, 2014 /PRNewswire/ -- Long-term non-invasive positive pressure ventilation (NPPV) – also known as non-invasive ventilation -- significantly improved long-term survival, exercise capacity, and health-related quality of life when added to current guidelines for the treatment of patients with advanced-stage chronic obstructive pulmonary disease (COPD). This is according to a new multi-center, randomized study published online in The Lancet Respiratory Medicine, and co-funded by ResMed (NYSE: RMD), the global leader in the treatment of sleep-disordered breathing and other respiratory conditions. COPD is the third leading cause of death in the U.S. and is expected to be the third leading cause of death worldwide by 2030. 

New Findings Have Potential to Alter Future Treatment ProtocolsLong-term NPPV has been shown to improve important physiological variables impacted by the disease, such as blood gases, but until now, there has been minimal clinical evidence for positive effects on longevity and quality of life in patients with COPD. These new findings demonstrate that NPPV can offer important benefits for patients with severe COPD, and are likely to influence clinical guidelines for therapy of these patients.

"Going forward, I would suggest that long-term NPPV will be considered in COPD patients with chronic moderate to severe hypercapnia," said Dr. Thomas Kohnlein, M.D., the principal author of the study and a member of the Department of Respiratory Medicine at Hannover Medical School, Hannover, Germany. "Previous prospective studies on NPPV for the treatment of COPD were performed using relatively low inspiratory pressures, failing to reduce hypercapnia, a side-effect of advanced COPD, and overlooking the potential benefits of higher press
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SOURCE ResMed Inc.
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